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ECB-ART-46507
Biomed Res Int 2018 Jan 01;2018:9875319. doi: 10.1155/2018/9875319.
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Effects of Diacetyl Flavoring Exposure in Mice Metabolism.

Jedlicka LDL , Silva JDC , Balbino AM , Neto GB , Furtado DZS , da Silva HDT , Cavalcanti FBC , van der Heijden KM , Penatti CAA , Bechara EJH , Assunção NA .


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Diacetyl is a flavoring that imparts a buttery flavor to foods, but the use or exposure to diacetyl has been related to some diseases. We investigated the effect of oral intake of diacetyl in male and female C57/Bl mice. We performed a target metabolomics assay using ultraperformance liquid chromatography paired with triple quadrupole mass spectrometry (UPLC-MS/MS) for the determination and quantification of plasmatic metabolites. We observed alterations in metabolites present in the urea and tricarboxylic acid (TCA) cycles. Peroxynitrite plasmatic levels were evaluated by a colorimetric method, final activity of superoxide dismutase (SOD) was evaluated by an enzymatic method, and mouse behavior was evaluated. Majority of the assay showed differences between control and treatment groups, as well as between genders. This may indicate the involvement of sex hormones in the regulation of a normal metabolic profile, and the implication of sex differences in metabolite disease response.

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Genes referenced: LOC583082 sod1


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References [+] :
Alonso, Sex differences in behavioral despair: relationships between behavioral despair and open field activity. 1991, Pubmed