Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-46424
Med Mol Morphol 2019 Mar 01;521:15-22. doi: 10.1007/s00795-018-0198-7.
Show Gene links Show Anatomy links

Physical exercise alters hepatic morphology of low-density lipoprotein receptor knockout ovariectomized mice.

Rodrigues FM , Adélio JI , Santana VO , De Marco Ornelas E , de Souza RR , Cardoso CG , da Veiga GL , Fonseca FLA , Maifrino LBM .


???displayArticle.abstract???
To explore the effects of physical exercise on the liver of animals in menopause, we analyzed the histomorphometric parameters of the hepatic tissue in ovariectomized and dyslipidemic female mice. The animals were distributed in six groups (n = 5): sedentary control (SC), sedentary ovariectomized control (SOC), trained ovariectomized control (TOC), sedentary LDL knockout (LDL-S), sedentary ovariectomized LDL knockout (LDL-SO), and trained ovariectomized LDL knockout (LDL-TO). At the end of the experiment, the liver and the visceral adipose tissue (VAT) of animals were removed for morphometric and stereological studies. In the LDL-S and LDL-SO animals, both sedentary, results showed reduction in the area (µm2) and major and minor diameters (µm) of hepatocytes and reduction in the portions of large hepatocytes, and increase in the percentage of Kupffer cells. The trained group showed a tendency of increase in the area and diameter and in the percentage of hepatocytes, as well significant reduction in the percentage of Kupffer cells and interstitial tissue. We suggested that training can prevent cell and tissue damage caused by the process of increase in hepatic fat, lipoperoxidation, and tissue inflammation in animals with privation of estrogen and dyslipidemia, apparently reflecting a better metabolic response of the hepatic tissue in organisms undergoing training.

???displayArticle.pubmedLink??? 29934711
???displayArticle.link??? Med Mol Morphol


Genes referenced: fat4 LOC115919910 LOC115925415

References [+] :
Berglund, Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver. 2011, Pubmed