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ECB-ART-46320
Nat Commun 2018 May 08;91:1819. doi: 10.1038/s41467-018-04155-2.
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Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo.

Chen Q , Shi J , Tao Y , Zernicka-Goetz M .


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A fundamental question in developmental and stem cell biology concerns the origin and nature of signals that initiate asymmetry leading to pattern formation and self-organization. Instead of having prominent pre-patterning determinants as present in model organisms (worms, sea urchin, frog), we propose that the mammalian embryo takes advantage of more subtle cues such as compartmentalized intracellular reactions that generate micro-scale inhomogeneity, which is gradually amplified over several cellular generations to drive pattern formation while keeping developmental plasticity. It is therefore possible that by making use of compartmentalized information followed by its amplification, mammalian embryos would follow general principle of development found in other organisms in which the spatial cue is more robustly presented.

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Species referenced: Echinodermata
Genes referenced: carm1 cdx1l LOC100887844 LOC115919910 LOC583082


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References [+] :
Achim, High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin. 2015, Pubmed