Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Anthocidins A⁻D, New 5-Hydroxyanthranilic Acid Related Metabolites from the Sea Urchin-Associated Actinobacterium, Streptomyces sp. HDa1.
Guo ZK
,
Wang R
,
Chen SQ
,
Chen FX
,
Liu TM
,
Yang MQ
.
???displayArticle.abstract???
Four new 5-hydroxyanthranilic acid related compounds, named anthocidins A⁻D (1⁻4), two known analogues n-lauryl 5-hydroxyanthranilate (5) and isolauryl 5-hydroxyanthranilate (6), together with benzamide (7), 3-hydroxy-4-methoxycinnamamide (8), and (3S-cis)-hexahydro-3-[(3,4-dihydroxyphenyl)methyl]pyrrolo[1,2-a]pyrazine-1,4-dione (9), were isolated from the fermentation broth of the marine-derived actinomycete, Streptomyces sp. HDa1, which was isolated from the gut of a sea urchin, Anthocidaris crassispina, collected from Hainan Island, China. The structures of these secondary metabolites were elucidated on the basis of their 1D and 2D-NMR and mass spectroscopic data, and anthocidin A was confirmed by single-crystal X-ray diffraction with Cu Kα radiation. Anthocidins A⁻D (1⁻4) feature an acetyl group substitution at the amino group and varying alkyl side chains at the carboxyl group of 5-hydroxyanthranilic acid, and compound 5 was isolated as a natural product for the first time. The cytotoxic and antibacterial activity of compounds 1⁻9 were evaluated.
Abdelmohsen,
Diversity, abundance and natural products of marine sponge-associated actinomycetes.
2014, Pubmed
Abdelmohsen,
Diversity, abundance and natural products of marine sponge-associated actinomycetes.
2014,
Pubmed
Abdelmohsen,
Actinomycetes from Red Sea sponges: sources for chemical and phylogenetic diversity.
2014,
Pubmed
Abdelmohsen,
Dereplication strategies for targeted isolation of new antitrypanosomal actinosporins A and B from a marine sponge associated-Actinokineospora sp. EG49.
2014,
Pubmed
Bae,
QM-HiFSA-Aided Structure Determination of Succinilenes A-D, New Triene Polyols from a Marine-Derived Streptomyces sp.
2017,
Pubmed
Baltz,
Renaissance in antibacterial discovery from actinomycetes.
2008,
Pubmed
Blunt,
Marine natural products.
2017,
Pubmed
,
Echinobase
Eltamany,
New antibacterial xanthone from the marine sponge-derived Micrococcus sp. EG45.
2014,
Pubmed
Gong,
Tetrocarcin Q, a New Spirotetronate with a Unique Glycosyl Group from a Marine-Derived Actinomycete Micromonospora carbonacea LS276.
2018,
Pubmed
Guo,
New Antibacterial Phenone Derivatives Asperphenone A-C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1.
2018,
Pubmed
Guo,
Metabolites with Insecticidal Activity from Aspergillus fumigatus JRJ111048 Isolated from Mangrove Plant Acrostichum specioum Endemic to Hainan Island.
2017,
Pubmed
Jin,
Fluostatins M-Q Featuring a 6-5-6-6 Ring Skeleton and High Oxidized A-Rings from Marine Streptomyces sp. PKU-MA00045.
2018,
Pubmed
Lacret,
MDN-0170, a New Napyradiomycin from Streptomyces sp. Strain CA-271078.
2016,
Pubmed
Linder,
The total synthesis of siphonazole, a structurally unusual bis-oxazole natural product.
2007,
Pubmed
Mosmann,
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
1983,
Pubmed
Ohkuma,
5-Hydroxyanthranilic acid derivatives as potent 5-lipoxygenase inhibitors.
1993,
Pubmed
Wang,
Spiculisporic acids B–D, three new γ-butenolide derivatives from a sea urchin-derived fungus Aspergillus sp. HDf2.
2012,
Pubmed
,
Echinobase
Wiegand,
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances.
2008,
Pubmed
Yang,
Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069.
2017,
Pubmed
