ECB-ART-46130
Free Radic Biol Med
2018 May 01;119:75-84. doi: 10.1016/j.freeradbiomed.2018.02.013.
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An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clock.
Peliciari-Garcia RA
,
Darley-Usmar V
,
Young ME
.
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At various biological levels, mammals must integrate with 24-hr rhythms in their environment. Daily fluctuations in stimuli/stressors of cardiac metabolism and oxidation-reduction (redox) status have been reported over the course of the day. It is therefore not surprising that the heart exhibits dramatic oscillations in various cellular processes over the course of the day, including transcription, translation, ion homeostasis, metabolism, and redox signaling. This temporal partitioning of cardiac processes is governed by a complex interplay between intracellular (e.g., circadian clocks) and extracellular (e.g., neurohumoral factors) influences, thus ensuring appropriate responses to daily stimuli/stresses. The purpose of the current article is to review knowledge regarding control of metabolism and redox biology in the heart over the course of the day, and to highlight whether disruption of these daily rhythms contribute towards cardiac dysfunction observed in various disease states.
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???displayArticle.grants??? [+]
R01 HL123574 NHLBI NIH HHS , R21 HL106199 NHLBI NIH HHS , R01 HL074259 NHLBI NIH HHS , R01 HL142216 NHLBI NIH HHS , R01 HL122975 NHLBI NIH HHS , P30 AG050886 NIA NIH HHS
Genes referenced: clock
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