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Life Sci
2018 Mar 15;197:30-39. doi: 10.1016/j.lfs.2018.01.031.
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Temporal partitioning of adaptive responses of the murine heart to fasting.
Brewer RA
,
Collins HE
,
Berry RD
,
Brahma MK
,
Tirado BA
,
Peliciari-Garcia RA
,
Stanley HL
,
Wende AR
,
Taegtmeyer H
,
Rajasekaran NS
,
Darley-Usmar V
,
Zhang J
,
Frank SJ
,
Chatham JC
,
Young ME
.
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Recent studies suggest that the time of day at which food is consumed dramatically influences clinically-relevant cardiometabolic parameters (e.g., adiposity, insulin sensitivity, and cardiac function). Meal feeding benefits may be the result of daily periods of feeding and/or fasting, highlighting the need for improved understanding of the temporal adaptation of cardiometabolic tissues (e.g., heart) to fasting. Such studies may provide mechanistic insight regarding how time-of-day-dependent feeding/fasting cycles influence cardiac function. We hypothesized that fasting during the sleep period elicits beneficial adaptation of the heart at transcriptional, translational, and metabolic levels. To test this hypothesis, temporal adaptation was investigated in wild-type mice fasted for 24-h, or for either the 12-h light/sleep phase or the 12-h dark/awake phase. Fasting maximally induced fatty acid responsive genes (e.g., Pdk4) during the dark/active phase; transcriptional changes were mirrored at translational (e.g., PDK4) and metabolic flux (e.g., glucose/oleate oxidation) levels. Similarly, maximal repression of myocardial p-mTOR and protein synthesis rates occurred during the dark phase; both parameters remained elevated in the heart of fasted mice during the light phase. In contrast, markers of autophagy (e.g., LC3II) exhibited peak responses to fasting during the light phase. Collectively, these data show that responsiveness of the heart to fasting is temporally partitioned. Autophagy peaks during the light/sleep phase, while repression of glucose utilization and protein synthesis is maximized during the dark/active phase. We speculate that sleep phase fasting may benefit cardiac function through augmentation of protein/cellular constituent turnover.
Arble,
Circadian timing of food intake contributes to weight gain.
2009, Pubmed
Arble,
Circadian timing of food intake contributes to weight gain.
2009,
Pubmed
Bray,
Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice.
2013,
Pubmed
Bray,
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.
2008,
Pubmed
Bray,
Time-of-day-dependent dietary fat consumption influences multiple cardiometabolic syndrome parameters in mice.
2010,
Pubmed
Chomczynski,
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
1987,
Pubmed
Davis,
Night shift work, light at night, and risk of breast cancer.
2001,
Pubmed
Durgan,
Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin.
2006,
Pubmed
Durgan,
The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids.
2006,
Pubmed
Durgan,
O-GlcNAcylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clock.
2011,
Pubmed
Egan,
The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR.
2011,
Pubmed
Finck,
Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart.
2002,
Pubmed
Gamble,
Circadian clock control of endocrine factors.
2014,
Pubmed
Gibson,
A novel method for real time quantitative RT-PCR.
1996,
Pubmed
Harmancey,
Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart.
2015,
Pubmed
Hatori,
Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.
2012,
Pubmed
Heid,
Real time quantitative PCR.
1996,
Pubmed
Kim,
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
2011,
Pubmed
Knutsson,
Shift work and diabetes--a systematic review.
2014,
Pubmed
Martino,
Influence of the cardiomyocyte circadian clock on cardiac physiology and pathophysiology.
2015,
Pubmed
McGinnis,
Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart.
2017,
Pubmed
McHill,
Later circadian timing of food intake is associated with increased body fat.
2017,
Pubmed
McKee,
Measurement of the rate of protein synthesis and compartmentation of heart phenylalanine.
1978,
Pubmed
Paula-Gomes,
Insulin suppresses atrophy- and autophagy-related genes in heart tissue and cardiomyocytes through AKT/FOXO signaling.
2013,
Pubmed
Peliciari-Garcia,
Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice.
2016,
Pubmed
,
Echinobase
Ruiz-Lozano,
Timing of food intake is associated with weight loss evolution in severe obese patients after bariatric surgery.
2016,
Pubmed
Sciarretta,
Mammalian target of rapamycin signaling in cardiac physiology and disease.
2014,
Pubmed
Sinturel,
Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles.
2017,
Pubmed
Spitzer,
Effect of lactate infusion on canine myocardial free fatty acid metabolism in vivo.
1974,
Pubmed
Stavinoha,
Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids.
2004,
Pubmed
Stavinoha,
Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle.
2004,
Pubmed
Stowe,
Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy.
2006,
Pubmed
Takahashi,
The genetics of mammalian circadian order and disorder: implications for physiology and disease.
2008,
Pubmed
Tsai,
Influence of dark phase restricted high fat feeding on myocardial adaptation in mice.
2013,
Pubmed
Tsai,
Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock.
2010,
Pubmed
Vyas,
Shift work and vascular events: systematic review and meta-analysis.
2012,
Pubmed
Wieland,
Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion.
1971,
Pubmed
Wu,
Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.
2001,
Pubmed
Young,
Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids.
2001,
Pubmed
Young,
Temporal partitioning of cardiac metabolism by the cardiomyocyte circadian clock.
2016,
Pubmed
Young,
Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart.
2001,
Pubmed
