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Mar Drugs
2017 Sep 30;1510:. doi: 10.3390/md15100301.
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Fucoidan and Fucosylated Chondroitin Sulfate Stimulate Hematopoiesis in Cyclophosphamide-Induced Mice.
Anisimova N
,
Ustyuzhanina N
,
Bilan M
,
Donenko F
,
Usov A
,
Kiselevskiy M
,
Nifantiev N
.
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Application of cytostatics in cancer patients'' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magnum (PS-FCS), were studied as stimulators of hematopoiesis after cyclophosphamide immunosuppression in mice. Recombinant granulocyte colony-stimulating factor (r G-CSF) was applied as a reference. Both tested polysaccharides PS-Fuc and PS-FCS have a similar activity to r G-CSF, causing pronounced neutropoiesis stimulation in animals with myelosuppression induced by cyclophosphamide (CPh). Moreover, these compounds are also capable to enhance thrombopoiesis and erythropoiesis. It should be noted that PS-FCS demonstrated a greater activity than r G-CSF. The results indicate the perspective of further studies of PS-Fuc and PS-FCS, since these compounds can be considered as potentially promising stimulators of hematopoiesis. Such drugs are in demand for the accompanying treatment of cancer patients who suffer from hematological toxicity during chemo and/or radiation therapy.
Figure 1. A dominant structural fragment of fucoidan (PS-Fuc) from the seaweed Chordaria flagelliformis [20] and the repeating unit of fucosylated chondroitin sulfate (PS-FCS) from the sea cucumber Massinium magnum [14].
Figure 2. Hematologic parameters of mice with CPh-induced immunosuppression after the treatment with PS-Fuc, PS-FCS and r G-CSF: (a) WBC; (b) neutrophils; (c) red blood cells (RBC); (d) platelets; (e) hemoglobin. Intact animals were characterized as a control.
Figure 3. Morphology of the spleen of mice with CPh-induced immunosuppression after treatment by tested substances compared to intact animals (hematoxylin-eosin staining): (a) CPh; (b) CPh + PS-Fuc; (c) CPh + PS-FCS; (d) CPh + r G-CSF; (e) control. Original magnification × 400.
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