Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Stem Cells Transl Med
2017 Oct 01;610:1917-1929. doi: 10.1002/sctm.17-0065.
Show Gene links
Show Anatomy links
Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cells: Preclinical Efficacy and Safety in Cervical Spinal Cord Injury.
Manley NC
,
Priest CA
,
Denham J
,
Wirth ED
,
Lebkowski JS
.
???displayArticle.abstract???
Cervical spinal cord injury (SCI) remains an important research focus for regenerative medicine given the potential for severe functional deficits and the current lack of treatment options to augment neurological recovery. We recently reported the preclinical safety data of a human embryonic cell-derived oligodendrocyte progenitor cell (OPC) therapy that supported initiation of a phase I clinical trial for patients with sensorimotor complete thoracic SCI. To support the clinical use of this OPC therapy for cervical injuries, we conducted preclinical efficacy and safety testing of the OPCs in a nude rat model of cervical SCI. Using the automated TreadScan system to track motor behavioral recovery, we found that OPCs significantly improved locomotor performance when administered directly into the cervical spinal cord 1 week after injury, and that this functional improvement was associated with reduced parenchymal cavitation and increased sparing of myelinated axons within the injury site. Based on large scale biodistribution and toxicology studies, we show that OPC migration is limited to the spinal cord and brainstem and did not cause any adverse clinical observations, toxicities, allodynia, or tumors. In combination with previously published efficacy and safety data, the results presented here supported initiation of a phase I/IIa clinical trial in the U.S. for patients with sensorimotor complete cervical SCI. Stem Cells Translational Medicine 2017;6:1917-1929.
All,
Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.
2015, Pubmed
All,
Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.
2015,
Pubmed
Almad,
Oligodendrocyte fate after spinal cord injury.
2011,
Pubmed
Alsanie,
Human embryonic stem cell-derived oligodendrocytes: protocols and perspectives.
2013,
Pubmed
Anderson,
Acceptable benefits and risks associated with surgically improving arm function in individuals living with cervical spinal cord injury.
2009,
Pubmed
Anderson,
Pathophysiology of spinal cord trauma.
1993,
Pubmed
Baastrup,
Pain in spinal cord injury.
2012,
Pubmed
Basso,
A sensitive and reliable locomotor rating scale for open field testing in rats.
1995,
Pubmed
Boyd,
Human embryonic stem cell-derived mesoderm-like epithelium transitions to mesenchymal progenitor cells.
2009,
Pubmed
Cummings,
Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice.
2005,
Pubmed
Douvaras,
Efficient generation of myelinating oligodendrocytes from primary progressive multiple sclerosis patients by induced pluripotent stem cells.
2014,
Pubmed
Ek,
Spatio-temporal progression of grey and white matter damage following contusion injury in rat spinal cord.
2010,
Pubmed
Fawcett,
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials.
2007,
Pubmed
Geissler,
Rodent Models and Behavioral Outcomes of Cervical Spinal Cord Injury.
2013,
Pubmed
Gensel,
Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats.
2006,
Pubmed
Hosier,
A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury.
2015,
Pubmed
Hu,
Differentiation of human oligodendrocytes from pluripotent stem cells.
2009,
Pubmed
Hu,
Glial scar and neuroregeneration: histological, functional, and magnetic resonance imaging analysis in chronic spinal cord injury.
2010,
Pubmed
Hulsebosch,
Rodent model of chronic central pain after spinal cord contusion injury and effects of gabapentin.
2000,
Pubmed
Huselstein,
Mesenchymal stem cells for cartilage engineering.
2012,
Pubmed
Kadoya,
Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration.
2016,
Pubmed
Kakulas,
The applied neuropathology of human spinal cord injury.
1999,
Pubmed
Karimi-Abdolrezaee,
Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury.
2006,
Pubmed
Keirstead,
Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury.
2005,
Pubmed
Ko,
Gross quantitative measurements of spinal cord segments in human.
2004,
Pubmed
Lee,
A contusive model of unilateral cervical spinal cord injury using the infinite horizon impactor.
2012,
Pubmed
Li,
Expansion of human embryonic stem cells in defined serum-free medium devoid of animal-derived products.
2005,
Pubmed
Metz,
Validation of the weight-drop contusion model in rats: a comparative study of human spinal cord injury.
2000,
Pubmed
Muramoto,
Midkine overcomes neurite outgrowth inhibition of chondroitin sulfate proteoglycan without glial activation and promotes functional recovery after spinal cord injury.
2013,
Pubmed
Nistor,
Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation.
2005,
Pubmed
Norenberg,
The pathology of human spinal cord injury: defining the problems.
2004,
Pubmed
Osaka,
Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome.
2010,
Pubmed
Patel,
Serial Diffusion Tensor Imaging In Vivo Predicts Long-Term Functional Recovery and Histopathology in Rats following Different Severities of Spinal Cord Injury.
2016,
Pubmed
Perrin,
Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury.
2010,
Pubmed
Piao,
Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
2015,
Pubmed
Priest,
Preclinical safety of human embryonic stem cell-derived oligodendrocyte progenitors supporting clinical trials in spinal cord injury.
2015,
Pubmed
,
Echinobase
Quertainmont,
Mesenchymal stem cell graft improves recovery after spinal cord injury in adult rats through neurotrophic and pro-angiogenic actions.
2012,
Pubmed
Raghothaman,
Engineering cell matrix interactions in assembled polyelectrolyte fiber hydrogels for mesenchymal stem cell chondrogenesis.
2014,
Pubmed
Scheff,
Experimental modeling of spinal cord injury: characterization of a force-defined injury device.
2003,
Pubmed
Schroeder,
The Use of Cell Transplantation in Spinal Cord Injuries.
2016,
Pubmed
Sharp,
Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury.
2010,
Pubmed
Shin,
Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury.
2015,
Pubmed
Walker,
Biphasic bisperoxovanadium administration and Schwann cell transplantation for repair after cervical contusive spinal cord injury.
2015,
Pubmed
Wang,
Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.
2013,
Pubmed
Xu,
Feeder-free growth of undifferentiated human embryonic stem cells.
2001,
Pubmed
Yang,
Generation of oligodendroglial cells by direct lineage conversion.
2013,
Pubmed
Zhang,
Oligodendrocyte progenitor cells derived from human embryonic stem cells express neurotrophic factors.
2006,
Pubmed
