Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Antifungal and Ichthyotoxic Sesquiterpenoids from Santalum album Heartwood.
Kim TH
,
Hatano T
,
Okamoto K
,
Yoshida T
,
Kanzaki H
,
Arita M
,
Ito H
.
???displayArticle.abstract???
In our continuing study on a survey of biologically active natural products from heartwood of Santalum album (Southwest Indian origin), we newly found potent fish toxic activity of an n-hexane soluble extract upon primary screening using killifish (medaka) and characterized α-santalol and β-santalol as the active components. The toxicity (median tolerance limit (TLm) after 24 h at 1.9 ppm) of α-santalol was comparable with that of a positive control, inulavosin (TLm after 24 h at 1.3 ppm). These fish toxic compounds including inulavosin were also found to show a significant antifungal effect against a dermatophytic fungus, Trichophyton rubrum. Based on a similarity of the morphological change of the immobilized Trichophyton hyphae in scanning electron micrographs between treatments with α-santalol and griseofulvin (used as the positive control), inhibitory effect of α-santalol on mitosis (the antifungal mechanism proposed for griseofulvin) was assessed using sea urchin embryos. As a result, α-santalol was revealed to be a potent antimitotic agent induced by interference with microtubule assembly. These data suggested that α-santalol or sandalwood oil would be promising to further practically investigate as therapeutic agent for cancers as well as fungal skin infections.
ANDERSON,
GRISEOFULVIN: BIOLOGY AND CLINICAL USEFULNESS. A REVIEW.
1965, Pubmed
ANDERSON,
GRISEOFULVIN: BIOLOGY AND CLINICAL USEFULNESS. A REVIEW.
1965,
Pubmed
Banerjee,
Modulatory influence of sandalwood oil on mouse hepatic glutathione S-transferase activity and acid soluble sulphydryl level.
1993,
Pubmed
Bauer,
Antibiotic susceptibility testing by a standardized single disk method.
1966,
Pubmed
Benencia,
Antiviral activity of sandalwood oil against herpes simplex viruses-1 and -2.
1999,
Pubmed
Cunningham,
Rotenone, an anticarcinogen, inhibits cellular proliferation but not peroxisome proliferation in mouse liver.
1995,
Pubmed
Dwivedi,
Chemopreventive effects of alpha-santalol on skin tumor development in CD-1 and SENCAR mice.
2003,
Pubmed
Dwivedi,
Chemopreventive effects of sandalwood oil on skin papillomas in mice.
1997,
Pubmed
Dwivedi,
Sandalwood oil prevent skin tumour development in CD1 mice.
1999,
Pubmed
Fujita,
Inulavosin, a melanogenesis inhibitor, leads to mistargeting of tyrosinase to lysosomes and accelerates its degradation.
2009,
Pubmed
Gomez,
Toxicants from mangrove plants, V. Isolation of the piscicide, 2-hydroxy-5-methoxy-3-undecyl-1,4 benzoquinone (5-O-methylembelin) from Aegiceras corniculatum.
1989,
Pubmed
Gull,
Griseofulvin inhibits fungal mitosis.
1973,
Pubmed
Hongratanaworakit,
Evaluation of the effects of East Indian sandalwood oil and alpha-santalol on humans after transdermal absorption.
2004,
Pubmed
Kanzaki,
Enzymatic conversion of cyclic dipeptides to dehydro derivatives that inhibit cell division.
2000,
Pubmed
,
Echinobase
Kaur,
Skin cancer chemopreventive agent, {alpha}-santalol, induces apoptotic death of human epidermoid carcinoma A431 cells via caspase activation together with dissipation of mitochondrial membrane potential and cytochrome c release.
2005,
Pubmed
Kim,
Aromatic constituents from the heartwood of Santalum album L.
2005,
Pubmed
Kim,
Bisabolane- and santalane-type sesquiterpenoids from Santalum album of Indian origin.
2005,
Pubmed
Lin,
Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin.
1989,
Pubmed
Okugawa,
Effects of sesquiterpenoids from "Oriental incenses" on acetic acid-induced writhing and D2 and 5-HT2A receptors in rat brain.
2000,
Pubmed
Okugawa,
Effect of α-santalol and β-santalol from sandalwood on the central nervous system in mice.
1995,
Pubmed
ROTH,
In vitro studies of the antifungal antibiotic griseofulvin.
1959,
Pubmed
