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Oncol Lett
2017 Mar 01;133:1847-1855. doi: 10.3892/ol.2017.5624.
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A polysaccharide component from Strongylocentrotus nudus eggs inhibited hepatocellular carcinoma in mice by activating T lymphocytes.
Zhang M
,
Liu Y
,
Li J
,
Ke M
,
Yu J
,
Dou J
,
Wang H
,
Zhou C
.
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A component purified from Strongylocentrotus nudus eggs on a diethylaminoethyl cellulose-52 chromatography column and eluted using a NaCl solution gradient (SEP-S), is a homogeneous polysaccharide of α-D-glucan with a reduced molecular weight of 9.33×105 Da, compared with that of S. nudus egg polysaccharide (SEP). In an in vivo antitumor assay of histocompatibility-22 hepatocellular carcinoma in tumor-bearing mice, the inhibitory rates at SEP-S doses of 5, 10 and 20 mg/kg/day were 38.8, 50.7 and 70.3%, respectively. In addition, the spleen and thymus indices and the percentages of cluster of differentiation (CD) 4+ and CD8+ T cells were significantly increased, and the activity of cytotoxic T lymphocytes was notably enhanced, suggesting that the anti-hepatocellular carcinoma activity is mediated by boosting the immune system. In vitro experiments also demonstrated that splenocyte proliferation induced by SEP-S was inhibited by the toll-like receptor (TLR) 2 and TLR4 monoclonal antibodies. These data indicate that SEP-S is a polysaccharide component possessing high anti-hepatocellular carcinoma activity and may be a potential immunotherapy candidate for the treatment of liver cancer.
Brown,
Dectin-1 mediates the biological effects of beta-glucans.
2003, Pubmed
Brown,
Dectin-1 mediates the biological effects of beta-glucans.
2003,
Pubmed
Chen,
Endo-polysaccharide of Phellinus igniarius exhibited anti-tumor effect through enhancement of cell mediated immunity.
2011,
Pubmed
Fan,
Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus.
2012,
Pubmed
Han,
Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus.
2003,
Pubmed
Hong,
Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models.
2004,
Pubmed
Huang,
Immunoenhancement effect of rehmannia glutinosa polysaccharide on lymphocyte proliferation and dendritic cell.
2013,
Pubmed
Ke,
The anti-lung cancer activity of SEP is mediated by the activation and cytotoxicity of NK cells via TLR2/4 in vivo.
2014,
Pubmed
,
Echinobase
Lee,
Protective effects of Paeonia lactiflora pall on hydrogen peroxide-induced apoptosis in PC12 cells.
2008,
Pubmed
Li,
Structural characterization of the polysaccharide moiety of an aqueous glycopeptide from mannatide.
2014,
Pubmed
Liu,
Induction of immunomodulating cytokines by a new polysaccharide-peptide complex from culture mycelia of Lentinus edodes.
1998,
Pubmed
Liu,
Immunomodulatory activity of polysaccharides isolated from Strongylocentrotus nudus eggs.
2008,
Pubmed
,
Echinobase
Ma,
Extraction, preliminary characterization and immunostimulatory activity in vitro of a polysaccharide isolated from Strongylocentrotus nudus eggs.
2014,
Pubmed
,
Echinobase
Miura,
Structure and biological activities of beta-glucans from yeast and mycelial forms of Candida albicans.
2003,
Pubmed
Mourão,
Searching for alternatives to heparin: sulfated fucans from marine invertebrates.
1999,
Pubmed
Nair,
Mechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora cordifolia.
2006,
Pubmed
Passos,
Influence of molecular weight on in vitro immunostimulatory properties of instant coffee.
2014,
Pubmed
Rashid,
A study of anti-cancer effects of Funalia trogii in vitro and in vivo.
2011,
Pubmed
Sahara,
In vivo anti-tumour effect of 3'-sulphonoquinovosyl 1'-monoacylglyceride isolated from sea urchin (Strongylocentrotus intermedius) intestine.
1997,
Pubmed
,
Echinobase
Sandel,
Natural killer cells infiltrating colorectal cancer and MHC class I expression.
2005,
Pubmed
Shiku,
Importance of CD4+ helper T-cells in antitumor immunity.
2003,
Pubmed
Swann,
Immune surveillance of tumors.
2007,
Pubmed
Wang,
Effective inhibition of a Strongylocentrotus nudus eggs polysaccharide against hepatocellular carcinoma is mediated via immunoregulation in vivo.
2011,
Pubmed
,
Echinobase
Wang,
A polysaccharide from Strongylocentrotus nudus eggs protects against myelosuppression and immunosuppression in cyclophosphamide-treated mice.
2011,
Pubmed
,
Echinobase
Xu,
Antitumor and immunomodulatory activity of polysaccharides from the roots of Actinidia eriantha.
2009,
Pubmed
Yadav,
The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria.
2006,
Pubmed
Yoon,
Toll-like receptor 4-dependent activation of macrophages by polysaccharide isolated from the radix of Platycodon grandiflorum.
2003,
Pubmed
Zhang,
Effects of the exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis on immunocytes of H22 tumor bearing mice.
2008,
Pubmed
