Hermawan I et al. (2017), Four Aromatic Sulfates with an Inhibitory Effec...

ECB-ART-45416

Mar Drugs 2017 Apr 11;154:. doi: 10.3390/md15040117.

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Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia.

Hermawan I , Furuta A , Higashi M , Fujita Y , Akimitsu N , Yamashita A , Moriishi K , Tsuneda S , Tani H , Nakakoshi M , Tsubuki M , Sekiguchi Y , Noda N , Tanaka J .

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Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1-4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1-4 showed moderate inhibition against NS3 helicase with IC50 values of 71, 95, 7, and 5 μM, respectively.

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Genes referenced: LOC587482

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References [+] :

Furuta, Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. 2015, Pubmed

	Figure 1. Structures of Compounds 1–4.
	Figure 2. Representative 2D NMR correlations in Compound 1.
	Figure 3. Structures of Compounds 5–7.
	Figure 4. Optimized geometries and comparison of NMR data for Compounds 1 and 5.
	Figure 5. Inhibition curves of Compounds 1–4 generated using the fluorescence helicase assay.