Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Rouxs Arch Dev Biol
1986 May 01;1954:252-258. doi: 10.1007/BF02438958.
Show Gene links
Show Anatomy links
Maternal stores of α subtype histone mRNAs are not required for normal early development of sea urchin embryos.
Wells DE
,
Anstrom JA
,
Raff RA
,
Murray SR
,
Showman RM
.
???displayArticle.abstract???
The ability to specifically delete the store of maternal α-subtype histone mRNAs stored in the egg pronucleus has allowed us to examine the role of this major fraction of the maternal mRNA in the early development of the sea urchinStrongylocentrotus purpuratus. The eggnucleus was removed by centrifugation, and the resulting enucleate half eggs were fertilized. These haploid andromerogones lacked any stored α-subtype histone mRNAs. However, when grown in parallel with control embryos, they showed identical cleavage cycles, cell numbers, and patterns of cell differentiation. Measurements of the amount of α-histone mRNA in these andromerogones showed that there was no premature synthesis of α-histone mRNAs to compensate for the deleted maternal pool. Instead embryonic synthesis was normal in timing of initiation and duration. the ability of these embryos to develop into highly differentiated larvae without their maternal α-subtype histone mRNA pool suggests that this pool is not a critical component of early development per se. This suggestion is strengthened by the observation that the primitive sea urchinEucidaris tribuloides naturally lacks this maternal histone mRNA store. Evolutionary implications are discussed.
Angerer,
Delayed accumulation of maternal histone mRNA during sea urchin oogenesis.
1984, Pubmed,
Echinobase
Angerer,
Delayed accumulation of maternal histone mRNA during sea urchin oogenesis.
1984,
Pubmed
,
Echinobase
Arceci,
Histone variants and chromatin structure during sea urchin development.
1980,
Pubmed
,
Echinobase
Cognetti,
Structural differences in the chromatin from compartmentalized cells of the sea urchin embryo: differential nuclease accessibility of micromere chromatin.
1981,
Pubmed
,
Echinobase
Cohen,
Stage-specific switches in histone synthesis during embryogenesis of the sea urchin.
1975,
Pubmed
,
Echinobase
DeLeon,
Most early-variant histone mRNA is contained in the pronucleus of sea urchin eggs.
1983,
Pubmed
,
Echinobase
Easton,
The relative contributions of newly synthesized and stored messages to Hl histone synthesis in interspecies hybrid echinoid embryos.
1979,
Pubmed
,
Echinobase
Herlands,
Translational regulation of histone synthesis in the sea urchin strongylocentrotus purpuratus.
1982,
Pubmed
,
Echinobase
Mauron,
Accumulation of individual histone mRNAs during embryogenesis of the sea urchin Strongylocentrotus purpuratus.
1982,
Pubmed
,
Echinobase
Maxson,
Accumulation of the early histone messenger RNAs during the development of Strongylocentrotus purpuratus.
1982,
Pubmed
,
Echinobase
Newrock,
Histone changes during chromatin remodeling in embryogenesis.
1978,
Pubmed
,
Echinobase
Poccia,
Transitions in histone variants of the male pronucleus following fertilization and evidence for a maternal store of cleavage-stage histones in the sera urchin egg.
1981,
Pubmed
,
Echinobase
Raff,
Origin of a gene regulatory mechanism in the evolution of echinoderms.
1984,
Pubmed
,
Echinobase
Salik,
Electrophoretic analysis of the stored histone pool in unfertilized sea urchin eggs: quantification and identification by antibody binding.
1981,
Pubmed
,
Echinobase
Senger,
Histones of sea urchin embryos. Transients in transcription, translation, and the composition of chromatin.
1978,
Pubmed
,
Echinobase
Shaw,
Shift in nucleosome populations during embryogenesis: microheterogeneity in nucleosomes during development of the sea urchin embryo.
1981,
Pubmed
,
Echinobase
Showman,
Message-specific sequestration of maternal histone mRNA in the sea urchin egg.
1982,
Pubmed
,
Echinobase
Simpson,
Modulation of nucleosome structure by histone subtypes in sea urchin embryos.
1981,
Pubmed
,
Echinobase
Wells,
Delayed recruitment of maternal histone H3 mRNA in sea urchin embryos.
1981,
Pubmed
,
Echinobase
Wells,
Prevalent RNA sequences of mitochondrial origin in sea urchin embryos.
1982,
Pubmed
,
Echinobase