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Rouxs Arch Dev Biol
1993 Feb 01;2023:144-151. doi: 10.1007/BF00365304.
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Accumulation of multiacetylated forms of histones by trichostatin A and its developmental consequences in early starfish embryos.
Ikegami S
,
Ooe Y
,
Shimizu T
,
Kasahara T
,
Tsuruta T
,
Kijima M
,
Yoshida M
,
Beppu T
.
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External application of 10 rig/ml (R)-trichostatin A (TSA), a potent and specific inhibitor of mammalian histone deacetylase, to the embryo of the starfish Asterina pectinifera inhibited development during the early gastrula stage before formation of mesenchyme cells. The TSA-sensitive period was limited to the mid-blastula stage before hatching. The pulse-chase experiment clearly demonstrated that TSA induced an accumulation of acetylated histone species in blastulae through inhibition of historic deacetylation. Similar blockage of development at the early gastrula stage was observed with n-butyrate, which has been known as a weak inhibitor of historic deacetylase. These results suggest an intimate role for historic acetylation-deacetylation equilibria in starfish development.
Allegra,
Affinity chromatographic purification of nucleosomes containing transcriptionally active DNA sequences.
1987, Pubmed
Allegra,
Affinity chromatographic purification of nucleosomes containing transcriptionally active DNA sequences.
1987,
Pubmed
Cousens,
Different accessibilities in chromatin to histone acetylase.
1979,
Pubmed
Csordas,
On the biological role of histone acetylation.
1990,
Pubmed
D'Anna,
Concentration-dependent effects of sodium butyrate in Chinese hamster cells: cell-cycle progression, inner-histone acetylation, histone H1 dephosphorylation, and induction of an H1-like protein.
1980,
Pubmed
Gorman,
Expression of recombinant plasmids in mammalian cells is enhanced by sodium butyrate.
1983,
Pubmed
Hebbes,
A direct link between core histone acetylation and transcriptionally active chromatin.
1988,
Pubmed
Isomura,
RNA synthesis in starfish embryos: developmental consequences of its inhibition by formycin.
1989,
Pubmed
,
Echinobase
Johnson,
Altered nucleosomes of active nucleolar chromatin contain accessible histone H3 in its hyperacetylated forms.
1987,
Pubmed
Klehr,
Scaffold-attached regions (SAR elements) mediate transcriptional effects due to butyrate.
1992,
Pubmed
Nagano,
Achromosomal cleavage of fertilized starfish eggs in the presence of aphidicolin.
1981,
Pubmed
,
Echinobase
Ridsdale,
Chicken erythrocyte polynucleosomes which are soluble at physiological ionic strength and contain linker histones are highly enriched in beta-globin gene sequences.
1987,
Pubmed
Riggs,
n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells.
1977,
Pubmed
Sealy,
The effect of sodium butyrate on histone modification.
1978,
Pubmed
Tsuchimori,
Adenosine induces dormancy in starfish blastulae.
1988,
Pubmed
,
Echinobase
Tsuji,
A new antifungal antibiotic, trichostatin.
1976,
Pubmed
Turner,
Histone acetylation and control of gene expression.
1991,
Pubmed
Yamada,
The fate of DNA originally existing in the zygote nucleus during achromosomal cleavage of fertilized echinoderm eggs in the presence of aphidicolin: microscopic studies with anti-DNA antibody.
1985,
Pubmed
,
Echinobase
Yoshida,
Effects of trichostatins on differentiation of murine erythroleukemia cells.
1987,
Pubmed
Yoshida,
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.
1990,
Pubmed
Yoshida,
Reversible arrest of proliferation of rat 3Y1 fibroblasts in both the G1 and G2 phases by trichostatin A.
1988,
Pubmed
