Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Dev Cell
2016 Dec 19;396:667-682. doi: 10.1016/j.devcel.2016.11.018.
Show Gene links
Show Anatomy links
Generic Theoretical Models to Predict Division Patterns of Cleaving Embryos.
Pierre A
,
Sallé J
,
Wühr M
,
Minc N
.
???displayArticle.abstract???
Life for all animals starts with a precise 3D choreography of reductive divisions of the fertilized egg, known as cleavage patterns. These patterns exhibit conserved geometrical features and striking interspecies invariance within certain animal classes. To identify the generic rules that may govern these morphogenetic events, we developed a 3D-modeling framework that iteratively infers blastomere division positions and orientations, and consequent multicellular arrangements. From a minimal set of parameters, our model predicts detailed features of cleavage patterns in the embryos of fishes, amphibians, echinoderms, and ascidians, as well as the genetic and physical perturbations that alter these patterns. This framework demonstrates that a geometrical system based on length-dependent microtubule forces that probe blastomere shape and yolk gradients, biased by cortical polarity domains, may dictate division patterns and overall embryo morphogenesis. These studies thus unravel the default self-organization rules governing early embryogenesis and how they are altered by deterministic regulatory layers.
Bjerknes,
Physical theory of the orientation of astral mitotic spindles.
1986, Pubmed
Bjerknes,
Physical theory of the orientation of astral mitotic spindles.
1986,
Pubmed
Bosveld,
Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis.
2016,
Pubmed
Dan,
On the system controlling the time fo micromere formation in sea urchin embryos.
1971,
Pubmed
,
Echinobase
Dan,
Studies on Unequal Cleavage in Sea Urchins III. Micromere Formation under Compression: (equal division/unequal division/micromere formation/Hertwig's rule/Balfour's rule).
1987,
Pubmed
,
Echinobase
Dan,
STUDIES ON UNEQUAL CLEAVAGE IN SEA URCHINS I. MIGRATION OF THE NUCLEI TO THE VEGETAL POLE.
1979,
Pubmed
,
Echinobase
Danilchik,
Intrinsic chiral properties of the Xenopus egg cortex: an early indicator of left-right asymmetry?
2006,
Pubmed
Desnitskiĭ,
[On the classification of the cleavage patterns in amphibian embryos].
2014,
Pubmed
Dogterom,
Measurement of the force-velocity relation for growing microtubules.
1997,
Pubmed
Drechsel,
A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos.
1997,
Pubmed
Goldstein,
Cell contacts orient some cell division axes in the Caenorhabditis elegans embryo.
1995,
Pubmed
Gönczy,
Mechanisms of asymmetric cell division: flies and worms pave the way.
2008,
Pubmed
Grill,
Spindle positioning by cortical pulling forces.
2005,
Pubmed
Hamaguchi,
Analysis of the Role of Astral Rays in Pronuclear Migration in Sand Dollar Eggs by the Colcemid-UV Method: (sperm aster/pronuclear migration/sand dollar/colcemid-UV method).
1986,
Pubmed
,
Echinobase
Heier,
Ploidy manipulation and induction of alternate cleavage patterns through inhibition of centrosome duplication in the early zebrafish embryo.
2015,
Pubmed
Hejnol,
A twist in time--the evolution of spiral cleavage in the light of animal phylogeny.
2010,
Pubmed
Iseto,
Ultrastructural studies on the centrosome-attracting body: electron-dense matrix and its role in unequal cleavages in ascidian embryos.
1999,
Pubmed
Kimmel,
Stages of embryonic development of the zebrafish.
1995,
Pubmed
Kozlowski,
Cortical microtubule contacts position the spindle in C. elegans embryos.
2007,
Pubmed
Kwon,
Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds.
2015,
Pubmed
Leonard,
Analysis of dishevelled localization and function in the early sea urchin embryo.
2007,
Pubmed
,
Echinobase
Maître,
Pulsatile cell-autonomous contractility drives compaction in the mouse embryo.
2015,
Pubmed
Minc,
Influence of cell geometry on division-plane positioning.
2011,
Pubmed
,
Echinobase
Minc,
Predicting division plane position and orientation.
2012,
Pubmed
Mitchison,
Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells.
2012,
Pubmed
Neff,
Experimental analyses of cytoplasmic rearrangements which follow fertilization and accompany symmetrization of inverted Xenopus eggs.
1984,
Pubmed
Negishi,
Localized PEM mRNA and protein are involved in cleavage-plane orientation and unequal cell divisions in ascidians.
2007,
Pubmed
Nishida,
Vegetal egg cytoplasm promotes gastrulation and is responsible for specification of vegetal blastomeres in embryos of the ascidian Halocynthia roretzi.
1996,
Pubmed
Nishikata,
The centrosome-attracting body, microtubule system, and posterior egg cytoplasm are involved in positioning of cleavage planes in the ascidian embryo.
1999,
Pubmed
Olivier,
Cell lineage reconstruction of early zebrafish embryos using label-free nonlinear microscopy.
2010,
Pubmed
Pelegri,
Identification of recessive maternal-effect mutations in the zebrafish using a gynogenesis-based method.
2004,
Pubmed
Pelegri,
A mutation in the zebrafish maternal-effect gene nebel affects furrow formation and vasa RNA localization.
2000,
Pubmed
Peng,
Differential regulation of disheveled in a novel vegetal cortical domain in sea urchin eggs and embryos: implications for the localized activation of canonical Wnt signaling.
2013,
Pubmed
,
Echinobase
Raff,
Constraint, flexibility, and phylogenetic history in the evolution of direct development in sea urchins.
1987,
Pubmed
,
Echinobase
Roegiers,
Phases of cytoplasmic and cortical reorganizations of the ascidian zygote between fertilization and first division.
1999,
Pubmed
Sawada,
Microtubules in ascidian eggs during meiosis, fertilization, and mitosis.
1988,
Pubmed
Schierenberg,
Embryological variation during nematode development.
2006,
Pubmed
Summers,
A Stereometric Analysis of Karyokinesis, Cytokinesis and Cell Arrangements during and following Fourth Cleavage Period in the Sea Urchin, Lytechinus variegatus: (sea urchin embryo/cell division patterns/stereo imaging/3-D reconstruction).
1993,
Pubmed
,
Echinobase
Tanaka,
EFFECTS OF THE SURFACTANTS ON THE CLEAVAGE AND FURTHER DEVELOPMENT OF THE SEA URCHIN EMBRYOS 1. THE INHIBITION OF MICROMERE FORMATION AT THE FOURTH CLEAVAGE.
1976,
Pubmed
,
Echinobase
Tanimoto,
Shape-motion relationships of centering microtubule asters.
2016,
Pubmed
,
Echinobase
Tassy,
The ANISEED database: digital representation, formalization, and elucidation of a chordate developmental program.
2010,
Pubmed
Théry,
Experimental and theoretical study of mitotic spindle orientation.
2007,
Pubmed
Tsou,
PAR-dependent and geometry-dependent mechanisms of spindle positioning.
2003,
Pubmed
Urven,
A role for non-muscle myosin II function in furrow maturation in the early zebrafish embryo.
2006,
Pubmed
Webb,
Localized calcium transients accompany furrow positioning, propagation, and deepening during the early cleavage period of zebrafish embryos.
1997,
Pubmed
Wennekamp,
A self-organization framework for symmetry breaking in the mammalian embryo.
2013,
Pubmed
Wühr,
How does a millimeter-sized cell find its center?
2009,
Pubmed
Wühr,
A model for cleavage plane determination in early amphibian and fish embryos.
2010,
Pubmed
Xiong,
Interplay of cell shape and division orientation promotes robust morphogenesis of developing epithelia.
2014,
Pubmed
Yokota,
Altering the position of the first horizontal cleavage furrow of the amphibian (Xenopus) egg reduces embryonic survival.
1992,
Pubmed
