Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mar Drugs
2016 Nov 03;1411:. doi: 10.3390/md14110205.
Show Gene links
Show Anatomy links
Ceramide as a Target of Marine Triterpene Glycosides for Treatment of Human Myeloid Leukemia.
Yun SH
,
Shin SW
,
Stonik VA
,
Park JI
.
???displayArticle.abstract???
Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood. Standard AML therapy requires intensive combination chemotherapy, which leads to significant treatment-related toxicity. The search for new, low toxic marine agents, inducing the generation of ceramide in leukemic cells is a new approach to improve the therapy of leukemia. This review focuses on the metabolism of sphingolipids, the role of ceramide in treating leukemia, and the antitumor activity, related to ceramide metabolism, of some marine metabolites, particularly stichoposides, triterpene glycosides extracted from sea cucumbers of the family Stichopodiidae.
Adada,
Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics.
2014, Pubmed
Adada,
Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics.
2014,
Pubmed
Bieberich,
N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells.
2000,
Pubmed
Brown,
Functions of lipid rafts in biological membranes.
1998,
Pubmed
Chalfant,
The structural requirements for ceramide activation of serine-threonine protein phosphatases.
2004,
Pubmed
Dagan,
Synthetic, non-natural sphingolipid analogs inhibit the biosynthesis of cellular sphingolipids, elevate ceramide and induce apoptotic cell death.
2003,
Pubmed
Dinur,
Human acid beta-glucosidase: isolation and amino acid sequence of a peptide containing the catalytic site.
1986,
Pubmed
Futerman,
The ins and outs of sphingolipid synthesis.
2005,
Pubmed
Futerman,
The complex life of simple sphingolipids.
2004,
Pubmed
Gault,
An overview of sphingolipid metabolism: from synthesis to breakdown.
2010,
Pubmed
Goñi,
Sphingomyelinases: enzymology and membrane activity.
2002,
Pubmed
Grabowski,
Gaucher disease. Enzymology, genetics, and treatment.
1993,
Pubmed
Granot,
Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs.
2006,
Pubmed
Gulbins,
Acid sphingomyelinase-derived ceramide signaling in apoptosis.
2002,
Pubmed
Hanada,
Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques.
2000,
Pubmed
Hanada,
Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism.
2003,
Pubmed
Hannun,
The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind.
2002,
Pubmed
Hannun,
Many ceramides.
2011,
Pubmed
Hannun,
Functions of ceramide in coordinating cellular responses to stress.
1996,
Pubmed
Heinrich,
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation.
2004,
Pubmed
Herr,
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis.
1997,
Pubmed
Iwai,
Ceramide increases oxidative damage due to inhibition of catalase by caspase-3-dependent proteolysis in HL-60 cell apoptosis.
2003,
Pubmed
James,
The role of vitamin D derivatives and retinoids in the differentiation of human leukaemia cells.
1997,
Pubmed
Kim,
Enhancing effects of ceramide derivatives on 1,25-dihydroxyvitamin D(3)-induced differentiation of human HL-60 leukemia cells.
2007,
Pubmed
Kim,
Bax-dependent apoptosis induced by ceramide in HL-60 cells.
2001,
Pubmed
Kim,
Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells.
2008,
Pubmed
Kitagawa,
[Bioactive marine natural products].
1988,
Pubmed
Kitatani,
The sphingolipid salvage pathway in ceramide metabolism and signaling.
2008,
Pubmed
Kitatani,
Role of Sphingolipids and Metabolizing Enzymes in Hematological Malignancies.
2015,
Pubmed
Kolesnick,
Compartmentalization of ceramide signaling: physical foundations and biological effects.
2000,
Pubmed
Langmann,
Transcription factors Sp1 and AP-2 mediate induction of acid sphingomyelinase during monocytic differentiation.
1999,
Pubmed
Laviad,
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate.
2008,
Pubmed
Levade,
Signalling sphingomyelinases: which, where, how and why?
1999,
Pubmed
Liu,
Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia.
2010,
Pubmed
Macchia,
Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues.
2001,
Pubmed
Maceyka,
Sphingolipid metabolites in inflammatory disease.
2014,
Pubmed
Mesicek,
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.
2010,
Pubmed
Nica,
Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK.
2008,
Pubmed
Novgorodov,
Positively charged ceramide is a potent inducer of mitochondrial permeabilization.
2005,
Pubmed
Obeid,
Programmed cell death induced by ceramide.
1993,
Pubmed
Ogretmen,
Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance.
2001,
Pubmed
Ogretmen,
Biologically active sphingolipids in cancer pathogenesis and treatment.
2004,
Pubmed
Okazaki,
Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
1994,
Pubmed
Okazaki,
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation.
1989,
Pubmed
Okazaki,
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
1990,
Pubmed
Park,
Acid ceramidase and human disease.
2006,
Pubmed
Park,
Ceramide synthases as potential targets for therapeutic intervention in human diseases.
2014,
Pubmed
Park,
Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers.
2014,
Pubmed
,
Echinobase
Pattingre,
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy.
2009,
Pubmed
Pitson,
Regulation of sphingosine kinase and sphingolipid signaling.
2011,
Pubmed
Pyne,
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease.
2009,
Pubmed
Rodriguez-Cuenca,
Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity.
2015,
Pubmed
Saba,
S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase.
2013,
Pubmed
Salma,
The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism.
2009,
Pubmed
Samsel,
The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts.
2004,
Pubmed
Sánchez,
Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation.
2008,
Pubmed
Scarlatti,
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1.
2004,
Pubmed
Ségui,
Sphingolipids as modulators of cancer cell death: potential therapeutic targets.
2006,
Pubmed
Stiban,
Ceramide synthases: roles in cell physiology and signaling.
2010,
Pubmed
Struckhoff,
Novel ceramide analogs as potential chemotherapeutic agents in breast cancer.
2004,
Pubmed
Strum,
Lipid second messengers. A role in cell growth regulation and cell cycle progression.
1997,
Pubmed
Taha,
A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death.
2006,
Pubmed
Tettamanti,
Salvage pathways in glycosphingolipid metabolism.
2003,
Pubmed
Truman,
Evolving concepts in cancer therapy through targeting sphingolipid metabolism.
2014,
Pubmed
Vilar,
A phase I dose-escalating study of ES-285, a marine sphingolipid-derived compound, with repeat dose administration in patients with advanced solid tumors.
2012,
Pubmed
Wrasidlo,
The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8.
2008,
Pubmed
Yamaji,
Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins.
2015,
Pubmed
Yun,
Stichoposide C induces apoptosis through the generation of ceramide in leukemia and colorectal cancer cells and shows in vivo antitumor activity.
2012,
Pubmed
,
Echinobase
Yun,
By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, stichoposide D inhibits growth of leukemia xenografts.
2015,
Pubmed
,
Echinobase
