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Mar Drugs
2016 Oct 19;1410:. doi: 10.3390/md14100189.
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Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus.
Kang JX
,
Kang YF
,
Han H
.
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Three new polyhydroxysteroidal glycosides, hesperuside A (1), B (2), and C (3), as well as a known novaeguinoside A (4), were isolated from the ethanol extract of starfish Craspidaster hesperus collected from the South China Sea. Their structures were elucidated by extensive spectroscopic methods and chemical evidence. The compounds 1-3 present unprecedented carbohydrate chain 3-O-methyl-β-d-galactopyranose, which differ from each other in the side chains. These compounds exhibited cytotoxicity against human tumor cells BEL-7402, MOLT-4, and A-549 in vitro.
Figure 1. The structures of compounds 1–4 isolated from starfish Craspidaster hesperus.
Figure 2. (A) Key correlations in the 1H, 1H-COSY (bold lines), HMBC (arrows point from protons to carbons); and (B) NOESY spectra of Hesperuside A (1).
Figure 3. Key HMBC correlations of the side chain of hesperuside C (3).
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