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Echinobase
ECB-ART-44931
J Nat Prod 2016 Oct 28;7910:2754-2757. doi: 10.1021/acs.jnatprod.6b00701.
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Curacin E from the Brittle Star Ophiocoma scolopendrina.

Ueoka R , Hitora Y , Ito A , Yoshida M , Okada S , Takada K , Matsunaga S .


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Bioassay-guided fractionation of the extract of the brittle star Ophiocoma scolopendrina afforded curacin E (1), a congener of curacin A (2). Curacin A (2) is an antimitotic agent of cyanobacterial origin. The structure of curacin E was studied by interpretation of NMR data and the ECD spectrum. Curacin E has an ethylcarbonyl terminus in its side chain and inhibits the proliferation of P388 cells.

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Genes referenced: ecd