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ECB-ART-44642
Biosci Biotechnol Biochem 2016 Oct 01;8010:1966-9. doi: 10.1080/09168451.2016.1176520.
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Effects of amino acid mutations in the pore-forming domain of the hemolytic lectin CEL-III.

Nagao T , Masaki R , Unno H , Goda S , Hatakeyama T .


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The hemolytic lectin CEL-III forms transmembrane pores in the membranes of target cells. A study on the effect of site-directed mutation at Lys405 in domain 3 of CEL-III indicated that replacements of this residue by relatively smaller residues lead to a marked increase in hemolytic activity, suggesting that moderately destabilizing domain 3 facilitates formation of transmembrane pores through conformational changes.

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