Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Int J Endocrinol
2016 Jan 01;2016:3797139. doi: 10.1155/2016/3797139.
Show Gene links
Show Anatomy links
The Influence of Alcohol Consumption in Conjunction with Sex Hormone Deficiency on Ca/P Ratio in Rats.
Lodi KB
,
Marchini AM
,
Santo AM
,
Rode Sde M
,
Marchini L
,
da Rocha RF
.
???displayArticle.abstract???
Deficiency of sex hormones and excessive alcohol consumption are factors that have been related to alterations in the pattern of bone mineralization and osteoporosis. The aim of this study was to evaluate possible alterations in the calcium/phosphorus (Ca/P) ratio in the femur of rats subjected to sex hormone deficiency and/or alcohol consumption. Methods. Female and male Wistar rats (n = 108) were divided into ovariectomized (Ovx), orchiectomized (Orx), or sham-operated groups and subdivided according to diet: alcoholic diet (20% alcohol solution), isocaloric diet, and ad libitum diet. The diets were administered for 8 weeks. The Ca/P ratio in the femur was analyzed by energy dispersive micro-X-ray spectrometer (μEDX). Results. Consumption of alcohol reduced the Ca/P ratio in both females and males. The isocaloric diet reduced the Ca/P ratio in females. In groups with the ad libitum diet, the deficiency of sex hormones did not change the Ca/P ratio in females or males. However, the combination of sex hormone deficiency and alcoholic diet presented the lowest values for the Ca/P ratio in both females and males. Conclusions. There was a reduced Ca/P ratio in the femur of rats that consumed alcohol, which was exacerbated when combined with a deficiency of sex hormones.
Figure 1. Weight changes (%): the graph illustrates the values of the averages (bars) and standard deviations (lines superimposing the bars). Statistical comparisons are summarized as follows: females: comparison between most of the groups showed no significant differences (NS). Statistical significances (p < 0.05) (∗) were observed in the following groups: G1/G3 (∗); G2/G3 (∗); G4/G3 (∗); G5/G3 (∗). Males: comparison between most of the groups showed no significant differences (NS). Statistical significances (p < 0.05) (∗) were observed in the following groups: G9/G7 (∗); G9/G8 (∗); G9/G11 (∗); G12/G7 (∗); G12/G8 (∗); G12/G11 (∗).
Figure 2. Ca (%): the graph illustrates the values of the averages (bars) and standard deviations (lines superimposing the bars). Statistical comparisons are summarized as follows: females: comparison between most of the groups showed statistical significance (p < 0.05). No significant differences (NS) were observed in the following groups: G2/G6 (NS); G4/G5 (NS). Males: comparison between most of the groups showed statistical significance (p < 0.05). No significant differences (NS) were observed in the following groups: G9/G12 (NS); G10/G7 (NS); G10/G8 (NS).
Figure 3. P (%): the graph illustrates the values of the averages (bars) and standard deviations (lines superimposing the bars). Statistical comparisons are summarized as follows: females: comparison between most of the groups showed statistical significance (p < 0.05). No significant differences (NS) were observed in the following groups: G1/G5 (NS); G2/G3 (NS); G2/G4 (NS), G3/G4 (NS). Males: comparison between most of the groups showed statistical significance (p < 0.05). No significant differences (NS) were observed between the following groups: G10/G12 (NS); G9/G10 (NS); G9/G12 (NS).
Figure 4. Ca/P: the graph illustrates the values of the averages (bars) and standard deviations (lines superimposing the bars). Statistical comparisons are summarized as follows: females: comparison between most of the groups showed statistical significance (p < 0.05). No significant differences (NS) were observed in the following groups: G3/G6 (NS). Males: comparison between most of the groups showed statistical significance (p < 0.05). No significant differences (NS) were observed in the following groups: G12/G9 (NS); G12/G11 (NS).
Alvisa-Negrín,
Osteopenia in alcoholics: effect of alcohol abstinence.
2009, Pubmed
Alvisa-Negrín,
Osteopenia in alcoholics: effect of alcohol abstinence.
2009,
Pubmed
Baraona,
Gender differences in pharmacokinetics of alcohol.
2001,
Pubmed
Barrios Ospino,
[Relation between leptin serun with weight and body fat distribution in postmenopausal women].
2010,
Pubmed
Callaci,
Binge alcohol treatment increases vertebral bone loss following ovariectomy: compensation by intermittent parathyroid hormone.
2006,
Pubmed
Calvo,
Is phosphorus intake that exceeds dietary requirements a risk factor in bone health?
2013,
Pubmed
Cauley,
Estrogen and bone health in men and women.
2015,
Pubmed
Chow,
Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation.
1992,
Pubmed
Clarke,
Normal bone anatomy and physiology.
2008,
Pubmed
De Oliveira,
Androgens and bone.
2012,
Pubmed
Falahati-Nini,
Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men.
2000,
Pubmed
Gamsjaeger,
Vibrational spectroscopic imaging for the evaluation of matrix and mineral chemistry.
2014,
Pubmed
Glaser,
Osteoporosis. Definition and clinical presentation.
1997,
Pubmed
Kelly,
Pattern and cause of fractures in patients who abuse alcohol: what should we do about it?
2013,
Pubmed
Khosla,
Estrogen and the skeleton.
2012,
Pubmed
Kourkoumelis,
Ca/P concentration ratio at different sites of normal and osteoporotic rabbit bones evaluated by Auger and energy dispersive X-ray spectroscopy.
2012,
Pubmed
Kourkoumelis,
Spectroscopic assessment of normal cortical bone: differences in relation to bone site and sex.
2010,
Pubmed
Lerner,
Bone remodeling in post-menopausal osteoporosis.
2006,
Pubmed
Lieber,
Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases.
2000,
Pubmed
Marchini,
Influence of chronic alcoholism and oestrogen deficiency on the variation of stoichiometry of hydroxyapatite within alveolar bone crest of rats.
2012,
Pubmed
Marchini,
Alcoholic and isocaloric diet, but not ovariectomy, influence the apoptosis of bone cells within the alveolar bone crest of rats.
2014,
Pubmed
Maurel,
Alcohol and bone: review of dose effects and mechanisms.
2012,
Pubmed
Maurel,
Regular exercise limits alcohol effects on trabecular, cortical thickness and porosity, and osteocyte apoptosis in the rat.
2013,
Pubmed
Meunier,
Bone mineral density reflects bone mass but also the degree of mineralization of bone: therapeutic implications.
1997,
Pubmed
Mikosch,
Alcohol and bone.
2014,
Pubmed
Mirand,
Total body water adjustment of mean alcohol intakes.
1994,
Pubmed
Moe,
Disorders involving calcium, phosphorus, and magnesium.
2008,
Pubmed
Pascon,
Morphological and chemical changes in dentin after using endodontic agents: fourier transform Raman spectroscopy, energy-dispersive x-ray fluorescence spectrometry, and scanning electron microscopy study.
2012,
Pubmed
Rachdaoui,
Effects of alcohol on the endocrine system.
2013,
Pubmed
Rajendram,
Effect of alcohol consumption on the gut.
2005,
Pubmed
Riggs,
Sex steroids and the construction and conservation of the adult skeleton.
2002,
Pubmed
Rizzoli,
Nutrition and bone health: turning knowledge and beliefs into healthy behaviour.
2014,
Pubmed
Rosa,
Chronic ethanol intake inhibits in vitro osteogenesis induced by osteoblasts differentiated from stem cells.
2008,
Pubmed
Schutz,
Role of substrate utilization and thermogenesis on body-weight control with particular reference to alcohol.
2000,
Pubmed
Sirichakwal,
Vitamin D Status Is Positively Associated with Calcium Absorption among Postmenopausal Thai Women with Low Calcium Intakes.
2015,
Pubmed
Soares,
Effects of Er:YAG laser irradiation and manipulation treatments on dentin components, part 2: energy-dispersive X-ray fluorescence spectrometry study.
2009,
Pubmed
Stein,
Skeletal structure in postmenopausal women with osteopenia and fractures is characterized by abnormal trabecular plates and cortical thinning.
2014,
Pubmed
Sumida,
Alcohol-induced suppression of gluconeogenesis is greater in ethanol fed female rat hepatocytes than males.
2007,
Pubmed
Tung,
Hydration and radiation effects on the residual stress state of cortical bone.
2013,
Pubmed
Wallen,
Body weight and food intake profiles are modulated by sex hormones and tamoxifen in chronically hypertensive rats.
2002,
Pubmed
Wang,
Altered distributions of bone tissue mineral and collagen properties in women with fragility fractures.
2016,
Pubmed
Zaichick,
Calcium and phosphorus concentrations and the calcium/phosphorus ratio in trabecular bone from the femoral neck of healthy humans as determined by neutron activation analysis.
2003,
Pubmed
Zhu,
Time-resolved dehydration-induced structural changes in an intact bovine cortical bone revealed by solid-state NMR spectroscopy.
2009,
Pubmed
de Deco,
Negative effects of alcohol intake and estrogen deficiency combination on osseointegration in a rat model.
2011,
Pubmed