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Biol Lett
2016 Jan 01;121:20150829. doi: 10.1098/rsbl.2015.0829.
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Blood transcriptomes reveal novel parasitic zoonoses circulating in Madagascar''s lemurs.
Larsen PA
,
Hayes CE
,
Williams CV
,
Junge RE
,
Razafindramanana J
,
Mass V
,
Rakotondrainibe H
,
Yoder AD
.
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Zoonotic diseases are a looming threat to global populations, and nearly 75% of emerging infectious diseases can spread among wildlife, domestic animals and humans. A ''One World, One Health'' perspective offers us an ideal framework for understanding and potentially mitigating the spread of zoonoses, and the island of Madagascar serves as a natural laboratory for conducting these studies. Rapid habitat degradation and climate change on the island are contributing to more frequent contact among humans, livestock and wildlife, increasing the potential for pathogen spillover events. Given Madagascar''s long geographical isolation, coupled with recent and repeated introduction of agricultural and invasive species, it is likely that a number of circulating pathogens remain uncharacterized in lemur populations. Thus, it is imperative that new approaches be implemented for de novo pathogen discovery. To this end, we used non-targeted deep sequencing of blood transcriptomes from two species of critically endangered wild lemurs (Indri indri and Propithecus diadema) to characterize blood-borne pathogens. Our results show several undescribed vector-borne parasites circulating within lemurs, some of which may cause disease in wildlife, livestock and humans. We anticipate that advanced methods for de novo identification of unknown pathogens will have broad utility for characterizing other complex disease transmission systems.
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26814226
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Brown,
Shifting ranges and conservation challenges for lemurs in the face of climate change.
2015, Pubmed
Brown,
Shifting ranges and conservation challenges for lemurs in the face of climate change.
2015,
Pubmed
Bublitz,
Pathogenic enterobacteria in lemurs associated with anthropogenic disturbance.
2015,
Pubmed
Frey,
Comparison of three next-generation sequencing platforms for metagenomic sequencing and identification of pathogens in blood.
2014,
Pubmed
Giardine,
Galaxy: a platform for interactive large-scale genome analysis.
2005,
Pubmed
Grabherr,
Full-length transcriptome assembly from RNA-Seq data without a reference genome.
2011,
Pubmed
Hamilton,
The evolution of Trypanosoma cruzi: the 'bat seeding' hypothesis.
2012,
Pubmed
Homer,
Babesiosis.
2000,
Pubmed
Jenkins,
Analysis of patterns of bushmeat consumption reveals extensive exploitation of protected species in eastern Madagascar.
2011,
Pubmed
Junge,
Effects of anthropogenic disturbance on indri (Indri indri) health in Madagascar.
2011,
Pubmed
Lipkin,
The changing face of pathogen discovery and surveillance.
2013,
Pubmed
McCoy,
Detection of Borrelia theileri in Rhipicephalus geigyi from Mali.
2014,
Pubmed
Pacheco,
Timing the origin of human malarias: the lemur puzzle.
2011,
Pubmed
Radford,
Application of next-generation sequencing technologies in virology.
2012,
Pubmed
Rar,
Anaplasma, Ehrlichia, and "Candidatus Neoehrlichia" bacteria: pathogenicity, biodiversity, and molecular genetic characteristics, a review.
2011,
Pubmed
Schwitzer,
Conservation. Averting lemur extinctions amid Madagascar's political crisis.
2014,
Pubmed
Springer,
Hemoparasites in a wild primate: Infection patterns suggest interaction of Plasmodium and Babesia in a lemur species.
2015,
Pubmed
Stamatakis,
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.
2014,
Pubmed
Stevens,
The ancient and divergent origins of the human pathogenic trypanosomes, Trypanosoma brucei and T. cruzi.
1999,
Pubmed
Stevens,
Evolutionary rate differences in trypanosomes.
2001,
Pubmed
Vayssier-Taussat,
Next generation sequencing uncovers unexpected bacterial pathogens in ticks in western Europe.
2013,
Pubmed