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Int J Endocrinol
2015 Jan 01;2015:146816. doi: 10.1155/2015/146816.
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Predictive Potential of Twenty-Two Biochemical Biomarkers for Coronary Artery Disease in Type 2 Diabetes Mellitus.
Pereira EC
,
Bertolami MC
,
Faludi AA
,
Monte O
,
Xavier HT
,
Pereira TV
,
Abdalla DS
.
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We investigated the potential of a panel of 22 biomarkers to predict the presence of coronary artery disease (CAD) in type 2 diabetes mellitus (DM2) patients. The study enrolled 96 DM2 patients with (n = 75) and without (n = 21) evidence of CAD. We assessed a biochemical profile that included 22 biomarkers: total cholesterol, LDL, HDL, LDL/HDL, triglycerides, glucose, glycated hemoglobin, fructosamine, homocysteine, cysteine, methionine, reduced glutathione, oxidized glutathione, reduced glutathione/oxidized glutathione, L-arginine, asymmetric dimethyl-L-arginine, symmetric dimethyl-L-arginine, asymmetric dimethyl-L-arginine/L-arginine, nitrate plus nitrite, S-nitrosothiols, nitrotyrosine, and n-acetyl-β-glucosaminidase. Prediction models were built using logistic regression models. We found that eight biomarkers (methionine, nitratate plus nitrite, n-acetyl-β-glucosaminidase, BMI, LDL, HDL, reduced glutathione, and L-arginine/asymmetric dimethyl-L-arginine) along with gender and BMI were significantly associated with the odds of CAD in DM2. These preliminary findings support the notion that emerging biochemical markers might be used for CAD prediction in patients with DM2. Our findings warrant further investigation with large, well-designed studies.
Augusto,
Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autooxidation: direct evidence for metal-independent formation of free radical intermediates.
1994, Pubmed
Augusto,
Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autooxidation: direct evidence for metal-independent formation of free radical intermediates.
1994,
Pubmed
Azuma,
Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L-arginine in regenerated endothelial cells.
1995,
Pubmed
Balint,
Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis.
2001,
Pubmed
Bouwmeester,
Reporting and methods in clinical prediction research: a systematic review.
2012,
Pubmed
Brownlee,
The pathobiology of diabetic complications: a unifying mechanism.
2005,
Pubmed
Bush,
Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction.
2008,
Pubmed
Böger,
Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia.
1998,
Pubmed
Cameron,
Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats.
1997,
Pubmed
Caussé,
Determination of asymmetrical dimethylarginine by capillary electrophoresis-laser-induced fluorescence.
2000,
Pubmed
Collins,
Developing risk prediction models for type 2 diabetes: a systematic review of methodology and reporting.
2011,
Pubmed
Cosentino,
Endothelial dysfunction in diabetes mellitus.
1998,
Pubmed
Elias,
Homocysteine concentrations in patients with diabetes mellitus--relationship to microvascular and macrovascular disease.
2005,
Pubmed
Ewing,
Specific S-nitrosothiol (thionitrite) quantification as solution nitrite after vanadium(III) reduction and ozone-chemiluminescent detection.
1998,
Pubmed
Farkas,
Proteins lose their nitric oxide stabilizing function after advanced glycosylation.
1995,
Pubmed
Gabir,
The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes.
2000,
Pubmed
Hogg,
Peroxynitrite and atherosclerosis.
1993,
Pubmed
Hogg,
The oxidation of alpha-tocopherol in human low-density lipoprotein by the simultaneous generation of superoxide and nitric oxide.
1993,
Pubmed
Hoogeveen,
Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes : 5-year follow-up of the Hoorn Study.
2000,
Pubmed
Inoue,
Serum N-acetyl-beta-D-gulucosaminidase activity increases in association with insulin resistance in patients with coronary artery disease.
2000,
Pubmed
Johansen,
Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice.
2005,
Pubmed
Komosińska-Vassev,
Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control.
2005,
Pubmed
Marley,
A chemiluminescense-based assay for S-nitrosoalbumin and other plasma S-nitrosothiols.
2000,
Pubmed
McDermott,
Studies on the catabolism of Ng-methylarginine, Ng, Ng-dimethylarginine and Ng, Ng-dimethylarginine in the rabbit.
1976,
Pubmed
Pereira,
Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis.
2007,
Pubmed
Pereira,
Biomarkers of oxidative stress and endothelial dysfunction in glucose intolerance and diabetes mellitus.
2008,
Pubmed
Pereira,
Empirical evaluation of very large treatment effects of medical interventions.
2012,
Pubmed
Pinkney,
Endothelial dysfunction: cause of the insulin resistance syndrome.
1997,
Pubmed
Reglero,
Glycosidases of molluscs. Purification and properties of alpha-L-fucosidase from Chamelea gallina L.
1976,
Pubmed
Skrha,
Comparison of laser-Doppler flowmetry with biochemical indicators of endothelial dysfunction related to early microangiopathy in Type 1 diabetic patients.
2001,
Pubmed
Skrha,
[Changes in microcirculation and selected laboratory parameters in the early stages of diabetic microangiopathy].
2001,
Pubmed
Skrha,
Serum alpha-tocopherol and ascorbic acid concentrations in Type 1 and Type 2 diabetic patients with and without angiopathy.
2003,
Pubmed
Sánchez-Hueso,
[Influence of glycemic blood glucose control and incipient diabetic nephropathy on the urinary excretion of N-acetyl-glucosaminidase (NAG) in diabetes mellitus].
1995,
Pubmed
Vecchione,
Determining sulfur-containing amino acids by capillary electrophoresis: a fast novel method for total homocyst(e)ine human plasma.
1999,
Pubmed
Witztum,
The oxidation hypothesis of atherosclerosis.
1994,
Pubmed
Wolff,
Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes.
1987,
Pubmed
Xiong,
Effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase in patients and rats with diabetes.
2005,
Pubmed
