Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Molecules
2015 May 07;205:8168-80. doi: 10.3390/molecules20058168.
Show Gene links
Show Anatomy links
Antitrypanosomal Acetylene Fatty Acid Derivatives from the Seeds of Porcelia macrocarpa (Annonaceae).
de Á Santos L
,
Cavalheiro AJ
,
Tempone AG
,
Correa DS
,
Alexandre TR
,
Quintiliano NF
,
Rodrigues-Oliveira AF
,
Oliveira-Silva D
,
Martins RC
,
Lago JH
.
???displayArticle.abstract???
Chagas'' disease is caused by a parasitic protozoan and affects the poorest population in the world, causing high mortality and morbidity. As a result of the toxicity and long duration of current treatments, the discovery of novel and more efficacious drugs is crucial. In this work, the hexane extract from seeds of Porcelia macrocarpa R.E. Fries (Annonaceae) displayed in vitro antitrypanosomal activity against trypomastigote forms of T. cruzi by the colorimetric MTT assay (IC50 of 65.44 μg/mL). Using chromatographic fractionation over SiO2, this extract afforded a fraction composed by one active compound (IC50 of 10.70 µg/mL), which was chemically characterized as 12,14-octadecadiynoic acid (macrocarpic acid). Additionally, two new inactive acetylene compounds (α,α''-dimacro-carpoyl-β-oleylglycerol and α-macrocarpoyl-α''-oleylglycerol) were also isolated from the hexane extract. The complete characterization of the isolated compounds was performed by analysis of NMR and MS data as well as preparation of derivatives.
BLIGH,
A rapid method of total lipid extraction and purification.
1959, Pubmed
BLIGH,
A rapid method of total lipid extraction and purification.
1959,
Pubmed
Barrett,
Management of trypanosomiasis and leishmaniasis.
2012,
Pubmed
Brandão,
Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds.
1997,
Pubmed
Carballeira,
2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.
2012,
Pubmed
Chaves,
Alkaloids from Porcelia macrocarpa.
2001,
Pubmed
Corrêa,
Anti-leishmanial and anti-trypanosomal potential of polygodial isolated from stem barks of Drimys brasiliensis Miers (Winteraceae).
2011,
Pubmed
Dal Picolo,
Antileishmanial activity evaluation of adunchalcone, a new prenylated dihydrochalcone from Piper aduncum L.
2014,
Pubmed
Engels,
Reconsidering the underestimated burden caused by neglected tropical diseases.
2006,
Pubmed
Grecco,
Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae).
2010,
Pubmed
,
Echinobase
Grecco,
In vitro antileishmanial and antitrypanosomal activities of flavanones from Baccharis retusa DC. (Asteraceae).
2012,
Pubmed
,
Echinobase
Grecco,
Anti-trypanosomal phenolic derivatives from Baccharis uncinella.
2014,
Pubmed
Kettler,
Engaging biotechnology companies in the development of innovative solutions for diseases of poverty.
2004,
Pubmed
Kraus,
New acetylenes isolated from the bark of Heisteria acuminata.
1998,
Pubmed
Kuklev,
Bioactive acetylenic metabolites.
2013,
Pubmed
Lago,
Evaluation of antifungal and DNA-damaging activities of alkaloids from branches of Porcelia macrocarpa.
2007,
Pubmed
Morais,
Antiparasitic activity of natural and semi-synthetic tirucallane triterpenoids from Schinus terebinthifolius (Anacardiaceae): structure/activity relationships.
2014,
Pubmed
,
Echinobase
Muller,
The determination and interpretation of the therapeutic index in drug development.
2012,
Pubmed
Rea,
Soulamarin isolated from Calophyllum brasiliense (Clusiaceae) induces plasma membrane permeabilization of Trypanosoma cruzi and mytochondrial dysfunction.
2013,
Pubmed
,
Echinobase
Schmidt,
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part I.
2012,
Pubmed
Senn,
Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii.
2007,
Pubmed
Setzer,
A cytotoxic diacetylene from Dendropanax arboreus.
1995,
Pubmed
Yamazoe,
Structure-activity relationship of acetylenes from galls of Hedera rhombea as plant growth inhibitors.
2006,
Pubmed
de Oliveira,
Leishmanicidal activity of an alkenylphenol from Piper malacophyllum is related to plasma membrane disruption.
2012,
Pubmed