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Ubiquitin-dependent proteosome-mediated proteolysis is an important pathway of degradation that controls the timed destruction of cellular proteins in all tissues. All intracellular proteins and many extracellular proteins are continually being hydrolyzed to their constituent amino acids as a result of their recognition by E3 ligases for specific targeting of ubiquitination. Gustavus is a member of an ECS-type E3 ligase which interacts with Vasa, a DEAD-box RNA helicase, to regulate its localization during sea urchin embryonic development, and Gustavus mRNA accumulation is highly localized and dynamic during development. We tested if the core complex for Gustavus function was present in the embryo and if other SOCS box proteins also had restricted expression profiles that would inform future research. Expression patterns of the key members of the proteasomal function, such as the E3 core complex which interacts with Gustavus, and other E3-SOCS box proteins, are widely spread and dynamic in early development of the embryo suggesting broad core complex availability in the proteasome degradation pathway and temporal/spatial enrichments of various E3 ligase dependent targeting mechanisms.
Amemiya,
Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration.
2008, Pubmed
Amemiya,
Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration.
2008,
Pubmed
Aragón,
Sumoylation: a new wrestler in the DNA repair ring.
2005,
Pubmed
Arenas-Mena,
Spatial expression of Hox cluster genes in the ontogeny of a sea urchin.
2000,
Pubmed
,
Echinobase
Bullock,
Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
2006,
Pubmed
Burger,
The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications.
2004,
Pubmed
Cameron,
SpBase: the sea urchin genome database and web site.
2009,
Pubmed
,
Echinobase
Canning,
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
2013,
Pubmed
Carrano,
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.
1999,
Pubmed
Chanet,
Regulation of epithelial polarity by the E3 ubiquitin ligase Neuralized and the Bearded inhibitors in Drosophila.
2012,
Pubmed
Daskalaki,
Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized.
2011,
Pubmed
Deblandre,
Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.
2001,
Pubmed
de Hostos,
Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits.
1991,
Pubmed
Denison,
Proteomic insights into ubiquitin and ubiquitin-like proteins.
2005,
Pubmed
Dohmen,
SUMO protein modification.
2004,
Pubmed
Fang,
A field guide to ubiquitylation.
2004,
Pubmed
Feldman,
A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.
1997,
Pubmed
Flores-Morales,
Negative regulation of growth hormone receptor signaling.
2006,
Pubmed
Fong,
Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs.
1986,
Pubmed
Gustafson,
Vasa genes: emerging roles in the germ line and in multipotent cells.
2010,
Pubmed
Gustafson,
Post-translational regulation by gustavus contributes to selective Vasa protein accumulation in multipotent cells during embryogenesis.
2011,
Pubmed
,
Echinobase
Hilton,
Negative regulators of cytokine signal transduction.
1999,
Pubmed
Hoey,
Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators.
1993,
Pubmed
Joazeiro,
RING finger proteins: mediators of ubiquitin ligase activity.
2000,
Pubmed
Juliano,
Germ line determinants are not localized early in sea urchin development, but do accumulate in the small micromere lineage.
2006,
Pubmed
,
Echinobase
Kamura,
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
1998,
Pubmed
Kibel,
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C.
1995,
Pubmed
Kile,
The SOCS box: a tale of destruction and degradation.
2002,
Pubmed
Kile,
Functional analysis of Asb-1 using genetic modification in mice.
2001,
Pubmed
Kim,
Stage-specific expression of ankyrin and SOCS box protein-4 (Asb-4) during spermatogenesis.
2008,
Pubmed
Kim,
Murine Asb-17 expression during mouse testis development and spermatogenesis.
2004,
Pubmed
Koutelou,
Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1.
2008,
Pubmed
Kugler,
Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors.
2010,
Pubmed
Lai,
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta.
2001,
Pubmed
Lasko,
The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A.
1988,
Pubmed
Lecker,
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.
2006,
Pubmed
Lee,
Expression of murine Asb-9 during mouse spermatogenesis.
2008,
Pubmed
Loram,
Age-related changes in gene expression in tissues of the sea urchin Strongylocentrotus purpuratus.
2012,
Pubmed
,
Echinobase
Mani,
The ubiquitin-proteasome pathway and its role in cancer.
2005,
Pubmed
Marmor,
Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases.
2004,
Pubmed
Metcalf,
Gigantism in mice lacking suppressor of cytokine signalling-2.
2000,
Pubmed
Pan,
Nedd8 on cullin: building an expressway to protein destruction.
2004,
Pubmed
Patton,
Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis.
1998,
Pubmed
Petroski,
Function and regulation of cullin-RING ubiquitin ligases.
2005,
Pubmed
Pickart,
Mechanisms underlying ubiquitination.
2001,
Pubmed
Pickart,
Ubiquitin: structures, functions, mechanisms.
2004,
Pubmed
Pryer,
Cytosolic Sec13p complex is required for vesicle formation from the endoplasmic reticulum in vitro.
1993,
Pubmed
Sawasdikosol,
Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase.
2000,
Pubmed
Suganuma,
Diverse functions of WD40 repeat proteins in histone recognition.
2008,
Pubmed
Tanaka,
Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway.
2001,
Pubmed
Tyers,
Proteolysis and the cell cycle: with this RING I do thee destroy.
2000,
Pubmed
Vaisman,
The role of Saccharomyces cerevisiae Cdc40p in DNA replication and mitotic spindle formation and/or maintenance.
1995,
Pubmed
Venkitachalam,
Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase.
2011,
Pubmed
Wei,
A database of mRNA expression patterns for the sea urchin embryo.
2006,
Pubmed
,
Echinobase
Whiting,
Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp (Csk-binding protein) and the SOCS box of SOCS1.
2012,
Pubmed
Williams,
The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex.
1991,
Pubmed
Zhang,
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
1999,
Pubmed
