Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-43191
Respir Physiol Neurobiol 2014 Feb 01;192:134-46. doi: 10.1016/j.resp.2013.12.012.
Show Gene links Show Anatomy links

Effects of Rho-kinase inhibition in lung tissue with chronic inflammation.

Righetti RF , Pigati PA , Possa SS , Habrum FC , Xisto DG , Antunes MA , Leick EA , Prado CM , Martins Mde A , Rocco PR , Tibério Ide F .


???displayArticle.abstract???
We evaluated whether Rho-kinase inhibition (Y-27632) modulated distal lung responsiveness, inflammation, extracellular matrix remodeling and oxidative stress activation in guinea pigs (GPs) with chronic allergic inflammation. GPs were submitted to inhalation of ovalbumin (OVA-2×/week/4 weeks). From the 5th inhalation on, the Rho-kinase inhibitor group animals were submitted to Y-27632 inhalation 10min before each inhalation of OVA. Seventy-two hours after the seventh inhalation, the oscillatory mechanics of the distal lung strips were assessed under the baseline condition and after the ovalbumin challenge. Subsequently, the lung slices were submitted to morphometry. Rho-kinase inhibition in the ovalbumin-exposed animals attenuated distal lung elastance and resistance, eosinophils, IL-2, IL-4, IL-5, IL-13, TIMP-1, MMP-9, TGF-β, IFN-γ, NF-κB and iNOS-positive cells and the volume fraction of 8-iso-PGF2α, elastic, collagen and actin in alveolar walls compared with the OVA group (P<0.05). Rho-kinase inhibition contributed to the control of distal lung responsiveness, eosinophilic and Th1/Th2 responses and extracellular matrix remodeling in an animal model of chronic allergic inflammation.

???displayArticle.pubmedLink??? 24373838
???displayArticle.link??? Respir Physiol Neurobiol


Genes referenced: LOC100893746 LOC590297 mmp7