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Echinobase
ECB-ART-43187
Mar Drugs 2013 Dec 24;121:54-68. doi: 10.3390/md12010054.
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Palmitic acid and ergosta-7,22-dien-3-ol contribute to the apoptotic effect and cell cycle arrest of an extract from Marthasterias glacialis L. in neuroblastoma cells.

Pereira DM , Correia-da-Silva G , Valentão P , Teixeira N , Andrade PB .


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We describe the effect of a chemically characterized lipophilic extract obtained from Marthasterias glacialis L. against human breast cancer (MCF-7) and human neuroblastoma (SH-SY5Y) cell lines. Evaluation of DNA synthesis revealed that both cell lines were markedly affected in a concentration-dependent way, the SH-SY5Y cell line being more susceptible. Cell cycle arrest was observed, an effect induced by the sterol, ergosta-7,22-dien-3-ol, present in the extract. Morphological evaluation of treated cells showed the advent of lipid droplets and chromatin condensation compatible with apoptosis, which was confirmed by the evaluation of caspase-3 and -9 activities. Palmitic acid was the main compound responsible for this apoptotic effect by a ceramide-independent mechanism that involved endoplasmic reticulum (ER)-stress with upregulation of CCAAT/-enhancer-binding protein homologous protein (CHOP).

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Genes referenced: asah2 LOC100893907 LOC115919910 LOC593358


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References [+] :
Altmann, Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents. 2007, Pubmed