Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
???displayArticle.abstract???
Vesicle trafficking and new membrane addition at the cleavage furrow have been extensively documented. However, less clear is the old idea that expansion at the cell poles occurs during cytokinesis. We find that new membrane is added to the cell poles during anaphase, causing the plasma membrane to expand coincident with the constriction of the contractile ring and may provide a pushing force for membrane ingression at the furrow. This membrane addition occurs earlier during mitosis than membrane addition at the furrow and is dependent on actin and astral microtubules. The membrane that is added at the polar regions is compositionally distinct from the original cell membrane in that it is devoid of GM(1) , a component of lipid rafts. These findings suggest that the growth of the plasma membrane at the cell poles during cell division is not due to stretching as previously thought, but due to the addition of compositionally unique new membrane.
Albertson,
Vesicles and actin are targeted to the cleavage furrow via furrow microtubules and the central spindle.
2008, Pubmed
Albertson,
Vesicles and actin are targeted to the cleavage furrow via furrow microtubules and the central spindle.
2008,
Pubmed
Albertson,
Membrane traffic: a driving force in cytokinesis.
2005,
Pubmed
Alford,
Cell polarity emerges at first cleavage in sea urchin embryos.
2009,
Pubmed
,
Echinobase
Badizadegan,
Floating cholera toxin into epithelial cells: functional association with caveolae-like detergent-insoluble membrane microdomains.
2000,
Pubmed
Belton,
Isolation and characterization of sea urchin egg lipid rafts and their possible function during fertilization.
2001,
Pubmed
,
Echinobase
Bluemink,
New membrane formation during cytokinesis in normal and cytochalasin B-treated eggs of Xenopus laevis. I. Electron microscope observations.
1973,
Pubmed
Boucrot,
Endosomal recycling controls plasma membrane area during mitosis.
2007,
Pubmed
BUCK,
An electron microscopic study of the cleavage furrow in mammalian cells.
1962,
Pubmed
Cao,
Mechanism of the formation of contractile ring in dividing cultured animal cells. II. Cortical movement of microinjected actin filaments.
1990,
Pubmed
Chichili,
Clustering of membrane raft proteins by the actin cytoskeleton.
2007,
Pubmed
Conner,
Syntaxin is required for cell division.
1999,
Pubmed
,
Echinobase
Fishkind,
Function of spindle microtubules in directing cortical movement and actin filament organization in dividing cultured cells.
1996,
Pubmed
Goodwin,
Photobleaching approaches to investigate diffusional mobility and trafficking of Ras in living cells.
2005,
Pubmed
Gromley,
Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission.
2005,
Pubmed
Guha,
Cortical actin turnover during cytokinesis requires myosin II.
2005,
Pubmed
Ishmael,
Nonmuscle myosins II-B and Va are components of detergent-resistant membrane skeletons derived from mouse forebrain.
2007,
Pubmed
Kwik,
Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin.
2003,
Pubmed
Liu,
Actin polymerization serves as a membrane domain switch in model lipid bilayers.
2006,
Pubmed
McKay,
'Life is a highway': membrane trafficking during cytokinesis.
2011,
Pubmed
Montagnac,
Endocytic traffic in animal cell cytokinesis.
2008,
Pubmed
Murthy,
Myosin-II-dependent localization and dynamics of F-actin during cytokinesis.
2005,
Pubmed
Neto,
Vesicle trafficking and membrane remodelling in cytokinesis.
2011,
Pubmed
Ng,
Movement of membrane domains and requirement of membrane signaling molecules for cytokinesis.
2005,
Pubmed
,
Echinobase
Rappaport,
Reversal of chemical cleavage inhibition in echinoderm eggs.
1971,
Pubmed
,
Echinobase
Rodgers,
Glycolipid-enriched membrane domains are assembled into membrane patches by associating with the actin cytoskeleton.
2001,
Pubmed
Sanger,
Cell surface changes during mitosis and cytokinesis of epithelial cells.
1984,
Pubmed
Schiel,
Making the final cut - mechanisms mediating the abscission step of cytokinesis.
2010,
Pubmed
Schweitzer,
Endocytosis resumes during late mitosis and is required for cytokinesis.
2005,
Pubmed
Shuster,
Targeted new membrane addition in the cleavage furrow is a late, separate event in cytokinesis.
2002,
Pubmed
,
Echinobase
Skop,
Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex.
2001,
Pubmed
Strickland,
Induction of cytokinesis is independent of precisely regulated microtubule dynamics.
2005,
Pubmed
,
Echinobase
Wang,
Single particle tracking of surface receptor movement during cell division.
1994,
Pubmed
Wilson,
The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.
2005,
Pubmed
Zhao,
Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancement.
2009,
Pubmed
