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ECB-ART-42505
Angew Chem Int Ed Engl 2012 Aug 20;5134:8640-3. doi: 10.1002/anie.201204578.
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A chemoenzymatic total synthesis of the neurogenic starfish ganglioside LLG-3 using an engineered and evolved synthase.

Rich JR , Withers SG .


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An LLG-3 oligosaccharide-fluoride can be assembled chemoenzymatically and readily coupled with various sphingosines by an engineered endoglycoceramidase glycosynthase. The lyso-ganglioside products are acylated to generate the individual isomers identified in the heterogeneous natural isolates, as well as modified glycosphingolipids.

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???displayArticle.link??? Angew Chem Int Ed Engl