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J Mol Evol
2012 Jun 01;745-6:319-31. doi: 10.1007/s00239-012-9509-0.
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Evolution of thrombin and other hemostatic proteases by survey of protochordate, hemichordate, and echinoderm genomes.
Ponczek MB
,
Bijak MZ
,
Nowak PZ
.
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Protochordate genomes enable a prevalence of hemostasis evolution. Broad searches were performed for homologs of human serine proteases of hemostasis on the genomes of Branchiostoma floridae, Saccoglossus kowalevskii, and Strongylocentrotus purpuratus. Sequences were analyzed by multiple bioinformatic tools. The survey revealed numerous homologous components. Amphioxus was rich in some serine proteases not accompanied by gamma-carboxyglutamic or kringle domains similar more to thrombin than to other coagulation factors. The serine proteases found in amphioxus exhibited the attributes similar to those of thrombin by phylogeny relationships, sequence conservation, gene synteny, spatial structure, and ligand docking. A few plasminogen- and plasminogen activators-like proteases with kringles were also present. Those serine proteases demonstrated the greatest proximity rather to plasminogen or plasminogen activators than to thrombin. Searching for homologs of serine protease hemostatic factors in acorn worm and sea urchin revealed several components similar to those found in amphioxus. Hypothetically, the common ancestor of chordates had three separate serine proteases that evolved independently into immunoglobulin-like and kringle proteases in lancelets, and prothrombin, plasminogen activators, and plasminogen in vertebrates. Ancestral proteases evolved in vertebrates into hemostasis factors after merging the proper N-terminal domains and duplications.
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997, Pubmed
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997,
Pubmed
Burge,
Prediction of complete gene structures in human genomic DNA.
1997,
Pubmed
Cai,
Reconstruction of ancestral protein sequences and its applications.
2004,
Pubmed
Carver,
ACT: the Artemis Comparison Tool.
2005,
Pubmed
Davidson,
450 million years of hemostasis.
2003,
Pubmed
Davidson,
Molecular evolution of the vertebrate blood coagulation network.
2003,
Pubmed
Dehal,
The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins.
2002,
Pubmed
Di Cera,
Serine proteases.
2009,
Pubmed
Di Cera,
Thrombin as an anticoagulant.
2011,
Pubmed
Di Cera,
Thrombin as procoagulant and anticoagulant.
2007,
Pubmed
Di Cera,
Thrombin.
2008,
Pubmed
Di Cera,
The Na+ binding site of thrombin.
1995,
Pubmed
Di Cera,
Thrombin interactions.
2003,
Pubmed
Doolittle,
Step-by-step evolution of vertebrate blood coagulation.
2009,
Pubmed
Doolittle,
Coagulation in vertebrates with a focus on evolution and inflammation.
2011,
Pubmed
Doolittle,
Reconstructing the evolution of vertebrate blood coagulation from a consideration of the amino acid sequences of clotting proteins.
1987,
Pubmed
Doolittle,
The evolution of vertebrate blood coagulation: a case of Yin and Yang.
1993,
Pubmed
Doolittle,
The protochordate Ciona intestinalis has a protein like full-length vertebrate fibrinogen.
2012,
Pubmed
Doolittle,
Genomic evidence for a simpler clotting scheme in jawless vertebrates.
2008,
Pubmed
Escriva,
Analysis of lamprey and hagfish genes reveals a complex history of gene duplications during early vertebrate evolution.
2002,
Pubmed
Fan,
Fibrinogen-related protein from amphioxus Branchiostoma belcheri is a multivalent pattern recognition receptor with a bacteriolytic activity.
2008,
Pubmed
Gandhi,
Structural basis of thrombin-protease-activated receptor interactions.
2011,
Pubmed
Gandhi,
Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1.
2010,
Pubmed
Guex,
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.
1997,
Pubmed
Henikoff,
Amino acid substitution matrices from protein blocks.
1992,
Pubmed
Huelsenbeck,
MRBAYES: Bayesian inference of phylogenetic trees.
2001,
Pubmed
Jiang,
The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes.
2003,
Pubmed
Kiefer,
The SWISS-MODEL Repository and associated resources.
2009,
Pubmed
Kimura,
Evolutionary origin of the vertebrate blood complement and coagulation systems inferred from liver EST analysis of lamprey.
2009,
Pubmed
Krem,
Evolution of enzyme cascades from embryonic development to blood coagulation.
2002,
Pubmed
Kulman,
Vitamin K-dependent proteins in Ciona intestinalis, a basal chordate lacking a blood coagulation cascade.
2006,
Pubmed
Lane,
Directing thrombin.
2005,
Pubmed
Letunic,
Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation.
2007,
Pubmed
Li,
Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.
2001,
Pubmed
Liu,
A kringle-containing protease with plasminogen-like activity in the basal chordate Branchiostoma belcheri.
2009,
Pubmed
Loof,
Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins?
2011,
Pubmed
Mathews,
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
1994,
Pubmed
McClay,
Evolutionary crossroads in developmental biology: sea urchins.
2011,
Pubmed
,
Echinobase
Nonaka,
Evolution of the complement system.
2004,
Pubmed
Oren,
Urochordate histoincompatible interactions activate vertebrate-like coagulation system components.
2008,
Pubmed
Peterson,
The Ediacaran emergence of bilaterians: congruence between the genetic and the geological fossil records.
2008,
Pubmed
Ponczek,
[The contact factors of hemostasis: examination of molecular evolution and new therapeutic perspectives].
2010,
Pubmed
Ponczek,
Evolution of the contact phase of vertebrate blood coagulation.
2008,
Pubmed
Putnam,
The amphioxus genome and the evolution of the chordate karyotype.
2008,
Pubmed
Riddel,
Theories of blood coagulation.
2007,
Pubmed
Schenone,
The blood coagulation cascade.
2004,
Pubmed
Smith,
The ancestral complement system in sea urchins.
2001,
Pubmed
,
Echinobase
Sodergren,
The genome of the sea urchin Strongylocentrotus purpuratus.
2006,
Pubmed
,
Echinobase
Sotriffer,
Automated docking of ligands to antibodies: methods and applications.
2000,
Pubmed
Stubbs,
The interaction of thrombin with fibrinogen. A structural basis for its specificity.
1992,
Pubmed
Suzuki,
C6-like and C3-like molecules from the cephalochordate, amphioxus, suggest a cytolytic complement system in invertebrates.
2002,
Pubmed
Thompson,
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
1994,
Pubmed
Trott,
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.
2010,
Pubmed
de Castro,
ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins.
2006,
Pubmed
