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Echinobase
ECB-ART-42402
Immun Ageing 2012 Apr 16;91:3. doi: 10.1186/1742-4933-9-3.
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Simple model systems: a challenge for Alzheimer''s disease.

Di Carlo M .


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The success of biomedical researches has led to improvement in human health and increased life expectancy. An unexpected consequence has been an increase of age-related diseases and, in particular, neurodegenerative diseases. These disorders are generally late onset and exhibit complex pathologies including memory loss, cognitive defects, movement disorders and death. Here, it is described as the use of simple animal models such as worms, fishes, flies, Ascidians and sea urchins, have facilitated the understanding of several biochemical mechanisms underlying Alzheimer''s disease (AD), one of the most diffuse neurodegenerative pathologies. The discovery of specific genes and proteins associated with AD, and the development of new technologies for the production of transgenic animals, has helped researchers to overcome the lack of natural models. Moreover, simple model systems of AD have been utilized to obtain key information for evaluating potential therapeutic interventions and for testing efficacy of putative neuroprotective compounds.

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Species referenced: Echinodermata
Genes referenced: aplp1 LOC100887844 LOC752081 LOC756768 ntf5 psen1


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References [+] :
Agnello, Apoptosis: Focus on sea urchin development. 2010, Pubmed, Echinobase