ECB-ART-42378
J Innate Immun
2012 Jan 01;45-6:478-88. doi: 10.1159/000336025.
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Contribution of alternatively activated macrophages to allergic lung inflammation: a tale of mice and men.
Dasgupta P
,
Keegan AD
.
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The concept that macrophages play an active role in inflammatory responses began its development in the late 1800s with the now iconic studies by Elie Metchnikoff using starfish larvae and Daphnia [reviewed in Kaufmann SHE: Nat Immunol 2008;9:705-712 and Cavaillon JM: J Leukoc Biol 2011;90:413-424]. Based on his observation of the phagocyte response to a foreign body (rose thorn) and yeast, he proposed that phagocytes acted in host defense and were active participants in the inflammatory process. Flash forward more than 100 years and we find that these basic tenets hold true. However, it is now appreciated that macrophages come in many different flavors and can adopt a variety of nuanced phenotypes depending on the tissue environment in which the macrophage is found. In this brief review, we discuss the role of one type of macrophage termed the alternatively activated macrophage (AAM), also known as the M2 type of macrophage, in regulating allergic lung inflammation and asthma. Recent studies using mouse models of allergic lung inflammation and samples from human asthma patients contribute to the emerging concept that AAMs are not just bystanders of the interleukin (IL)-4- and IL-13-rich environment found in allergic asthma but are also active players in orchestrating allergic lung disease.
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R01 AI038985 NIAID NIH HHS , R01 AI059775 NIAID NIH HHS , AI038985 NIAID NIH HHS , Intramural NIH HHS
References [+] :
Agapov,
Macrophage chitinase 1 stratifies chronic obstructive lung disease.
2009, Pubmed
Agapov, Macrophage chitinase 1 stratifies chronic obstructive lung disease. 2009, Pubmed
Anthony, Protective immune mechanisms in helminth infection. 2007, Pubmed
Anthony, Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. 2006, Pubmed
Artis, RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. 2004, Pubmed
Barlow, Nuocytes: expanding the innate cell repertoire in type-2 immunity. 2011, Pubmed
Barrett, Innate cells and T helper 2 cell immunity in airway inflammation. 2009, Pubmed
Bedoret, Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. 2009, Pubmed
Bhatia, Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype. 2011, Pubmed
Bierbaum, Polymorphisms and haplotypes of acid mammalian chitinase are associated with bronchial asthma. 2005, Pubmed
Brombacher, Analyzing classical and alternative macrophage activation in macrophage/neutrophil-specific IL-4 receptor-alpha-deficient mice. 2009, Pubmed
Busse, Mechanisms of asthma. 2003, Pubmed
Cai, Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation. 2009, Pubmed
Callard, IL-4 and IL-13 receptors: are they one and the same? 1996, Pubmed
Careau, Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness. 2004, Pubmed
Cavaillon, The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff. 2011, Pubmed
Chang, Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. 2011, Pubmed
Chen, Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza. 2012, Pubmed
Chensue, Role of IL-4 and IFN-gamma in Schistosoma mansoni egg-induced hypersensitivity granuloma formation. Orchestration, relative contribution, and relationship to macrophage function. 1992, Pubmed
Chupp, A chitinase-like protein in the lung and circulation of patients with severe asthma. 2007, Pubmed
Dasgupta, Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Rα and STAT6 dependent manner. 2011, Pubmed
Ford, Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation. 2012, Pubmed
Gessner, Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. 2005, Pubmed
Gordon, Alternative activation of macrophages: mechanism and functions. 2010, Pubmed
Gray, Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta. 2005, Pubmed
Gregory, Orchestrating house dust mite-associated allergy in the lung. 2011, Pubmed
Hammad, Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses. 2011, Pubmed
Hattori, Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations. 2009, Pubmed
Heller, Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages. 2008, Pubmed
Hesse, Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. 2001, Pubmed
Holcomb, FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. 2000, Pubmed
Holt, Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations. 2010, Pubmed
Jenkins, Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. 2011, Pubmed
Kaufmann, Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff. 2008, Pubmed
Kelly-Welch, Complex role of the IL-4 receptor alpha in a murine model of airway inflammation: expression of the IL-4 receptor alpha on nonlymphoid cells of bone marrow origin contributes to severity of inflammation. 2004, Pubmed
Kim, Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. 2008, Pubmed
Kurowska-Stolarska, IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. 2009, Pubmed
Lee, Chitin, chitinases and chitinase-like proteins in allergic inflammation and tissue remodeling. 2009, Pubmed
Lee, Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. 2009, Pubmed
Leonard, The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. 1996, Pubmed
Liu, Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4/IL-13 and mediation via STAT-6. 2004, Pubmed
Lohmann-Matthes, Pulmonary macrophages. 1994, Pubmed
Loke, IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype. 2002, Pubmed
Loke, Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. 2007, Pubmed
Louis, Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophages. 1999, Pubmed
Maarsingh, Increased arginase activity contributes to airway remodelling in chronic allergic asthma. 2011, Pubmed
Maizels, Helminth parasites--masters of regulation. 2004, Pubmed
Martinez, Alternative activation of macrophages: an immunologic functional perspective. 2009, Pubmed
McNally, Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells. 1995, Pubmed
Melgert, Macrophages: regulators of sex differences in asthma? 2010, Pubmed
Melgert, More alternative activation of macrophages in lungs of asthmatic patients. 2011, Pubmed
Moreno, IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin. 2007, Pubmed
Mosser, Exploring the full spectrum of macrophage activation. 2008, Pubmed
Munitz, Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. 2008, Pubmed
Nair, Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy. 2006, Pubmed
Nair, Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro. 2003, Pubmed
Nelms, The IL-4 receptor: signaling mechanisms and biologic functions. 1999, Pubmed
Niese, Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. 2009, Pubmed
North, Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. 2009, Pubmed
Ober, Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. 2008, Pubmed
Odegaard, Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. 2007, Pubmed
Odegaard, Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. 2008, Pubmed
Pesce, Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity. 2009, Pubmed
Pesce, Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. 2009, Pubmed
Raes, Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. 2005, Pubmed
Rauh, SHIP represses the generation of alternatively activated macrophages. 2005, Pubmed
Sandler, Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair. 2003, Pubmed
Shirey, Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent. 2010, Pubmed
Shirey, Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism. 2008, Pubmed
Stein, Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. 1992, Pubmed
Stout, Functional plasticity of macrophages: reversible adaptation to changing microenvironments. 2004, Pubmed
Stütz, The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism. 2003, Pubmed
Subrata, Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children. 2009, Pubmed
Tachdjian, In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. 2010, Pubmed
Teng, FIZZ1/RELMalpha, a novel hypoxia-induced mitogenic factor in lung with vasoconstrictive and angiogenic properties. 2003, Pubmed
Viksman, Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge. 2002, Pubmed
Voehringer, Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. 2007, Pubmed
Watanabe, Eotaxin-2 generation is differentially regulated by lipopolysaccharide and IL-4 in monocytes and macrophages. 2002, Pubmed
Weisser, Alternative activation of macrophages by IL-4 requires SHIP degradation. 2011, Pubmed
Welch, TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism. 2002, Pubmed
Wills-Karp, Innate lymphoid cells wield a double-edged sword. 2011, Pubmed
Wynn, Fibrotic disease and the T(H)1/T(H)2 paradigm. 2004, Pubmed
Yamaji-Kegan, Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism. 2010, Pubmed
Zhu, Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. 2004, Pubmed
Zimmermann, Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. 2004, Pubmed