ECB-ART-42327
Nat Prod Res
2013 Jan 01;272:117-22. doi: 10.1080/14786419.2012.660636.
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Bromotheoynic acid, a brominated acetylenic acid from the marine sponge Theonella swinhoei.
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A new brominated C(17) acetylenic acid (1) designated as bromotheoynic acid has been isolated from the marine sponge Theonella swinhoei, collected off the coast of Tanegashima, Kagoshima Prefecture, Japan. The structure was determined on the basis of the analysis of its extensive 2D NMR spectroscopic data as well as HRMS. Bromotheoynic acid (1) inhibited maturation of starfish oocytes and cell division of fertilised starfish eggs. Bromotheoynic acid (1) also inhibited proliferation of human leukaemia U937 and HL60 cells, human lung cancer A549 and H1299 cells, and human embryonic kidney 293 (HEK293) cells.
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Genes referenced: LOC115919910