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ECB-ART-42313
Drug Chem Toxicol 2012 Jul 01;353:324-9. doi: 10.3109/01480545.2011.619192.
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Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet.

Azzalis LA , Fonseca FL , Simon KA , Schindler F , Giavarotti L , Monteiro HP , Videla LA , Junqueira VB .


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Expression of cytochrome P4502E1 (CYP2E1) is very much influenced by nutritional factors, especially carbohydrate consumption, and various results concerning the expression of CYP2E1 were obtained with a low-carbohydrate diet. This study describes the effects of ethanol treatment on CYP2E1 levels and its relationship with oxidative stress using a balanced standard diet to avoid low or high carbohydrate consumption. Rats were fed for 1, 2, 3, or 4 weeks a commercial diet plus an ethanol-sucrose solution. The results have shown that ethanol administration was associated with CYP2E1 induction and stabilization without related oxidative stress. Our findings suggest that experimental models with a low-carbohydrate/high-fat diet produce some undesirable CYP2E1 changes that are not present when a balanced standard diet is given.

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Genes referenced: fat4