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Mol Biol Rep
2012 May 01;395:5811-8. doi: 10.1007/s11033-011-1391-0.
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Molecular characterization and expression profile of MAP2K1ip1/MP1 gene from tiger shrimp, Penaeus monodon.
Yang L
,
Liu X
,
Huang J
,
Yang Q
,
Qiu L
,
Liu W
,
Jiang S
.
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MAPK kinase 1 interacting protein 1 (MAP2K1ip1) is an important scaffold proteins of the mitogen-activated protein kinase (MAPK) pathway that form an active signaling module and enhance the specificity and spatiality of MAPK signaling. In the present study, we identified and characterized a MAP2K1ip1 cDNA from tiger shrimp Penaeus monodon (designated as PmMAP2K1ip1). The open reading frame of PmMAP2K1ip1 is 372 bp encoding 123 amino-acid residues with a MAPK interaction domain. The predicted PmMAP2Kip1 protein is 13.6 KDa with the theoretical isoelectric point of 6.3. PmMAP2K1ip1 shared the highest amino acid with Nasonia vitripennis and Strongylocentrotus purpuratus, at 48% and 47.5%, respectively. Phylogenic analysis shows PmMAP2Kip1 is clustering with SpMAP2Kip1, and close to the group of MAP2Kip1s from insect. Furthermore, semiquantitative RT-PCR revealed PmMAP2Kip1 is widely distributed in most examined tissues except nerve, and high expressed in ovary, hemocyte, intestines and hepatopancreas. Meanwhile, PmMAP2k1ip1 is expressed ubiquitously during larval and sex gland development, and keep a high level at the initial development stage. Quantitative real time RT-PCR revealed PmMAP2K1ip1 were up-regulated by lipopolysaccharide and peptidoglycan (PGN) in haemocyte. These data reveal MAP2K1ip1 is a multifunction protein that involved development and immune response. It is benefit to characterize other MAPK signal genes and elucidate the molecular regulation mechanism of MAPK signaling in tiger shrimp.
Brown,
Protein scaffolds in MAP kinase signalling.
2009, Pubmed
Brown,
Protein scaffolds in MAP kinase signalling.
2009,
Pubmed
Burlando,
Effects of seawater pollutants on protein tyrosine phosphorylation in mussel tissues.
2006,
Pubmed
Canesi,
Bacteria-hemocyte interactions and phagocytosis in marine bivalves.
2002,
Pubmed
Chang,
Mammalian MAP kinase signalling cascades.
2001,
Pubmed
Chen,
Effects of prenyl pyrophosphates on the binding of S-Ras proteins with KSR.
2002,
Pubmed
Cheng,
Expression and characterization of the JAK kinase and STAT protein from brine shrimp, Artemia franciscana.
2010,
Pubmed
Châtel,
Activation of MAP kinase signaling pathway in the mussel Mytilus galloprovincialis as biomarker of environmental pollution.
2010,
Pubmed
Feld,
Phosphorylation of extra-nuclear ERK/MAPK is required for long-term memory consolidation in the crab Chasmagnathus.
2005,
Pubmed
Gaitanaki,
Various stressors rapidly activate the p38-MAPK signaling pathway in Mytilus galloprovincialis (Lam.).
2004,
Pubmed
Huang,
Facilitated geranylgeranylation of shrimp ras-encoded p25 fusion protein by the binding with guanosine diphosphate.
1999,
Pubmed
Huang,
Identification and functional study of a shrimp Dorsal homologue.
2010,
Pubmed
Huang,
Identification and functional study of a shrimp Relish homologue.
2009,
Pubmed
KOZEK,
COMPARISON OF BLOOD STORED IN ACD AND IN A SOLUTION CONTAINING HEPARIN, PHOSPHATE, GLUCOSE AND ADENINE.
1964,
Pubmed
Kolch,
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.
2000,
Pubmed
Kornfeld,
The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
1995,
Pubmed
Kurzbauer,
Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes.
2004,
Pubmed
Lunin,
The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling.
2004,
Pubmed
Morrison,
Regulation of MAP kinase signaling modules by scaffold proteins in mammals.
2003,
Pubmed
Mouchel-Vielh,
Involvement of the MP1 scaffold protein in ERK signaling regulation during Drosophila wing development.
2008,
Pubmed
Mouchel-Vielh,
The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development.
2011,
Pubmed
Moyes,
A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells.
2010,
Pubmed
Nada,
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.
2009,
Pubmed
Pullikuth,
Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.
2007,
Pubmed
Qiu,
Molecular cloning and mRNA expression analysis of interleukin-8 gene in Japanese sea perch (Lateolabrax japonicus).
2009,
Pubmed
Schaeffer,
MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade.
1998,
Pubmed
Shaw,
A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.
1986,
Pubmed
Simon,
Q-Gene: processing quantitative real-time RT-PCR data.
2003,
Pubmed
Teis,
p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis.
2006,
Pubmed
Teis,
Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction.
2002,
Pubmed
Therrien,
A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila.
2000,
Pubmed
Thompson,
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
1997,
Pubmed
Wang,
An immune deficiency homolog from the white shrimp, Litopenaeus vannamei, activates antimicrobial peptide genes.
2009,
Pubmed
Wunderlich,
A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment.
2001,
Pubmed
Yang,
A Toll receptor in shrimp.
2007,
Pubmed
Ye,
Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia.
2008,
Pubmed