Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-42166
Mol Reprod Dev 2011 Jan 01;7810-11:757-68. doi: 10.1002/mrd.21380.
Show Gene links Show Anatomy links

Centrosome dynamics during mammalian oocyte maturation with a focus on meiotic spindle formation.

Schatten H , Sun QY .


???displayArticle.abstract???
Oocyte maturation is an important process required to achieve optimal oocyte quality, and later affects fertilization potential and subsequent embryo development. The maturation process includes synchronized nuclear and cytoplasmic remodeling, in which cytoskeletal and centrosome dynamics play an important role and significantly participate in cellular signaling. Centrosome remodeling within the maturing oocyte is essential for accurate meioisis I and II spindle formation, specifically to separate chromosomes accurately during the two successive, highly asymmetric meiotic cell divisions. Centrosomal abnormalities result in inaccurate microtubule organization and inaccurate chromosome alignment, with failures in chromosome segregation leading to aneuploidy and chromosomal abnormalities. The present review is focused on cytoskeletal and centrosome remodeling during oocyte maturation, with specific attention to γ-tubulin, pericentrin, the Nuclear Mitotic Apparatus (NuMA) protein, and microtubule organization. Species-specific differences will be discussed for rodent (mouse) and non-rodent (bovine, porcine) species, and for human oocytes.

???displayArticle.pubmedLink??? 21887720
???displayArticle.link??? Mol Reprod Dev


Genes referenced: LOC115919910 LOC582174 tubgcp2