Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Ertl RP
,
Robertson AJ
,
Saunders D
,
Coffman JA
.
???displayArticle.abstract??? Nodal proteins are diffusible morphogens that drive pattern formation via short-range feedback activation coupled to long-range Lefty-mediated inhibition. In the sea urchin embryo, specification of the secondary (oral-aboral) axis occurs via zygotic expression of nodal, which is localized to the prospective oral ectoderm at early blastula stage. In mid-blastula stage embryos treated with low micromolar nickel or zinc, nodal expression expands progressively beyond the confines of this localized domain to encompass the entire equatorial circumference of the embryo, producing radialized embryos lacking an oral-aboral axis. RNAseq analysis of embryos treated with nickel, zinc, or cadmium (which does not radialize embryos) showed that several genes involved in endocytosis were similarly perturbed by nickel and zinc but not cadmium. Inhibiting dynamin, a GTPase required for receptor-mediated endocytosis, phenocopies the effects of nickel and zinc, suggesting that dynamin-mediated endocytosis is required as a sink to limit the range of Nodal signaling.
Agca,
Respecification of ectoderm and altered Nodal expression in sea urchin embryos after cobalt and nickel treatment.
2009, Pubmed,
Echinobase
Agca,
Respecification of ectoderm and altered Nodal expression in sea urchin embryos after cobalt and nickel treatment.
2009,
Pubmed
,
Echinobase
Beane,
Lineage-specific expansions provide genomic complexity among sea urchin GTPases.
2006,
Pubmed
,
Echinobase
Bergeron,
Oral-aboral patterning and gastrulation of sea urchin embryos depend on sulfated glycosaminoglycans.
2011,
Pubmed
,
Echinobase
Blanchet,
Cripto localizes Nodal at the limiting membrane of early endosomes.
2008,
Pubmed
Bolouri,
The gene regulatory network basis of the "community effect," and analysis of a sea urchin embryo example.
2010,
Pubmed
,
Echinobase
Brooks,
The major yolk protein of sea urchins is endocytosed by a dynamin-dependent mechanism.
2004,
Pubmed
,
Echinobase
Cabeza,
Dynamics and regulation of endocytotic fission pores: role of calcium and dynamin.
2010,
Pubmed
Chea,
Nodal signaling and the evolution of deuterostome gastrulation.
2005,
Pubmed
,
Echinobase
Chen,
Two modes by which Lefty proteins inhibit nodal signaling.
2004,
Pubmed
Chen,
Lefty proteins are long-range inhibitors of squint-mediated nodal signaling.
2002,
Pubmed
Chen,
Inhibitors of clathrin-dependent endocytosis enhance TGFbeta signaling and responses.
2009,
Pubmed
Cheng,
Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors.
2004,
Pubmed
Crick,
Diffusion in embryogenesis.
1970,
Pubmed
Duboc,
Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo.
2004,
Pubmed
,
Echinobase
Duboc,
Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side.
2005,
Pubmed
,
Echinobase
Duboc,
Lefty acts as an essential modulator of Nodal activity during sea urchin oral-aboral axis formation.
2008,
Pubmed
,
Echinobase
Duboc,
Nodal and BMP2/4 pattern the mesoderm and endoderm during development of the sea urchin embryo.
2010,
Pubmed
,
Echinobase
Fernández-Chacón,
SCAMP1 function in endocytosis.
2000,
Pubmed
Flowers,
Nodal/activin signaling establishes oral-aboral polarity in the early sea urchin embryo.
2004,
Pubmed
,
Echinobase
Gierer,
A theory of biological pattern formation.
1972,
Pubmed
Grande,
Nodal signalling is involved in left-right asymmetry in snails.
2009,
Pubmed
,
Echinobase
Hardin,
Commitment along the dorsoventral axis of the sea urchin embryo is altered in response to NiCl2.
1992,
Pubmed
,
Echinobase
Juan,
Roles of nodal-lefty regulatory loops in embryonic patterning of vertebrates.
2001,
Pubmed
Lai,
The calcineurin-dynamin 1 complex as a calcium sensor for synaptic vesicle endocytosis.
1999,
Pubmed
Le Good,
Nodal stability determines signaling range.
2005,
Pubmed
Lupo,
Mechanisms of ventral patterning in the vertebrate nervous system.
2006,
Pubmed
Macia,
Dynasore, a cell-permeable inhibitor of dynamin.
2006,
Pubmed
McAbee,
Copper and zinc ions differentially block asialoglycoprotein receptor-mediated endocytosis in isolated rat hepatocytes.
1999,
Pubmed
Mortazavi,
Mapping and quantifying mammalian transcriptomes by RNA-Seq.
2008,
Pubmed
Nam,
Cis-regulatory control of the nodal gene, initiator of the sea urchin oral ectoderm gene network.
2007,
Pubmed
,
Echinobase
Nikonenko,
Inhibition of T-type calcium channels protects neurons from delayed ischemia-induced damage.
2005,
Pubmed
Range,
Cis-regulatory analysis of nodal and maternal control of dorsal-ventral axis formation by Univin, a TGF-beta related to Vg1.
2007,
Pubmed
,
Echinobase
Reynolds,
Early mRNAs, spatially restricted along the animal-vegetal axis of sea urchin embryos, include one encoding a protein related to tolloid and BMP-1.
1992,
Pubmed
,
Echinobase
Sakai,
Phospholipase C-dependent Ca2+-sensing pathways leading to endocytosis and inhibition of the plasma membrane vacuolar H+-ATPase in osteoclasts.
2010,
Pubmed
Sakuma,
Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.
2002,
Pubmed
Schier,
Nodal signalling in vertebrate development.
2000,
Pubmed
Shen,
Nodal signaling: developmental roles and regulation.
2007,
Pubmed
Solnica-Krezel,
Vertebrate development: taming the nodal waves.
2003,
Pubmed
Sorkin,
Endocytosis of growth factor receptors.
1993,
Pubmed
Su,
A perturbation model of the gene regulatory network for oral and aboral ectoderm specification in the sea urchin embryo.
2009,
Pubmed
,
Echinobase
Turing,
The chemical basis of morphogenesis. 1953.
1990,
Pubmed
Ungewickell,
Endocytosis: clathrin-mediated membrane budding.
2007,
Pubmed
Yaguchi,
A Wnt-FoxQ2-nodal pathway links primary and secondary axis specification in sea urchin embryos.
2008,
Pubmed
,
Echinobase
Yaguchi,
Sp-Smad2/3 mediates patterning of neurogenic ectoderm by nodal in the sea urchin embryo.
2007,
Pubmed
,
Echinobase
Yu,
Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules.
2009,
Pubmed
