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ECB-ART-41805
Org Biomol Chem 2011 Jan 07;91:278-90. doi: 10.1039/c0ob00396d.
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Synthesis of cyclic adenosine 5''-diphosphate ribose analogues: a C2''endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.

Moreau C , Ashamu GA , Bailey VC , Galione A , Guse AH , Potter BV .


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Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5''-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by (1)H NMR spectroscopy revealed that a C2''endo/syn conformation of the "southern" ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor.

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Genes referenced: LOC100887844 LOC115919910 rbpj


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References [+] :
Aarhus, ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP. 1995, Pubmed