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ECB-ART-41574
FEBS Lett 2010 Jun 03;58411:2279-84. doi: 10.1016/j.febslet.2010.03.036.
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Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and 11beta-hydroxysteroid dehydrogenase-type 3.

Baker ME .


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A key regulator of glucocorticoid action is 11beta-hydroxysteroid dehydrogenase-type 1 (11beta-HSD1), which catalyzes the conversion of cortisone to cortisol, the biologically active glucocorticoid. 11beta-HSD1 is a paralog of 11beta-HSD3, whose physiological function remains unclear. As reported here, 11beta-HSD3 has orthologs in sea urchin, amphioxus and Ciona, while 11beta-HSD1 first appears in sharks. Thus, 11beta-HSD3 arose before the evolution of glucocorticoid signaling, suggesting different ancestral function(s) for 11beta-HSD3. Four perplexing findings arise from this evolutionary analysis: (1) 11beta-HSD1 is not present in a ray-finned fish genome, (2) zebrafish and fathead minnow contain two isoforms of 11beta-HSD3; (3) neither rat nor mouse contain 11beta-HSD3 and (4) amphioxus contains 16 11beta-HSD3 paralogs.

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Genes referenced: LOC100887844 LOC100893480 LOC587800