Eye (Lond) 2009 Jun 01;236:1314-20. doi: 10.1038/eye.2008.296.

Vitreoretinal management of the complications of sickle cell retinopathy by observation or pars plana vitrectomy.

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PURPOSE: To describe the management of vitreoretinal complications of sickle cell retinopathy. DESIGN: A retrospective interventional case series. METHODS: Review of an electronic patient record and clinical notes of 27 patients with vitreoretinal complications of sickle retinopathy. RESULTS: Six male patients and 21 female patients presented with a mean age of 41 years (range 28-67), 12 left eyes and 16 right eyes. The mean follow-up was 15.5 months (range: 3-60). Two patients were SS, and the remainders were doubly heterozygous (SC). In all, 10 were observed without surgery- three with vitreous haemorrhage, four tractional retinal detachments (TRD), and three rhegmatogenous retinal detachments (RRD). Two patients demonstrated spontaneous flattening of the retina- one RRD and one TRD. Eighteen eyes had pars plana vitrectomies (PPVs)- seven with vitreous haemorrhage, three RRD, three TRD, three ERM (one bilateral), and two macular holes. In all, 15 patients (83%) had improved vision postoperatively. The mean logMar preoperative visual acuity was 1.07 (Snellen equivalent 6/70), SD 0.62 was significantly improved postoperatively (mean 0.42 (6/15), SD 0.48, P=0.001). CONCLUSIONS: Sickle retinopathy occasionally presents with vitreoretinal complications. These can often be observed and may spontaneously regress. If surgery is required eyes respond to vitrectomy procedures with segmentation of sea fan proliferation.

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Genes referenced: LOC100887844 LOC115919910