Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Parasitol Res
2009 Jan 01;1042:311-4. doi: 10.1007/s00436-008-1193-z.
Show Gene links
Show Anatomy links
Antiparasitic activity of biochanin A, an isolated isoflavone from fruits of Cassia fistula (Leguminosae).
Sartorelli P
,
Carvalho CS
,
Reimão JQ
,
Ferreira MJ
,
Tempone AG
.
???displayArticle.abstract???
The fractionation through bioguided antileishmanial activity of the dichloromethane extract of Cassia fistula fruits (Leguminosae) led to the isolation of the active isoflavone biochanin A, identified by spectroscopic methods. This compound showed 50% effective concentration (EC(50)) value of 18.96 microg/mL against promastigotes of Leishmania (L.) chagasi. The cytotoxicity of this substance against peritoneal macrophages resulted in an EC(50) value of 42.58 microg/mL. Additionally, biochanin A presented an anti-Trypanosoma-cruzi activity, resulting in an EC(50) value of 18.32 microg/mL and a 2.4-fold more effectiveness than benznidazole. These results contribute with novel antiprotozoal compounds for future drug design studies.
Agrawal,
Structure of fistulic acid, a new colouring matter from the pods of Cassia fistula.
1972, Pubmed
Agrawal,
Structure of fistulic acid, a new colouring matter from the pods of Cassia fistula.
1972,
Pubmed
Balaña-Fouce,
The pharmacology of leishmaniasis.
1998,
Pubmed
Benavides,
Flavonoids and isoflavonoids from Gynerium sagittatum.
2007,
Pubmed
Chan-Bacab,
Plant natural products with leishmanicidal activity.
2001,
Pubmed
Conceição,
Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis.
2006,
Pubmed
Croft,
Current scenario of drug development for leishmaniasis.
2006,
Pubmed
Iyengar,
Bioassay of Cassia fistula. L. (Aragvadha).
1966,
Pubmed
Lane,
In vitro trypanocidal activity of tetraethylthiuram disulfide and sodium diethylamine-N-carbodithioate on Trypanosoma cruzi.
1996,
Pubmed
Luximon-Ramma,
Antioxidant activities of phenolic, proanthocyanidin, and flavonoid components in extracts of Cassia fistula.
2002,
Pubmed
Moreira,
Synthesis and antitumour evaluation of peptidyl-like derivatives containing the 1,3-benzodioxole system.
2007,
Pubmed
,
Echinobase
Singh,
Challenges and new discoveries in the treatment of leishmaniasis.
2004,
Pubmed
Tada,
An improved colorimetric assay for interleukin 2.
1986,
Pubmed
Tasdemir,
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies.
2006,
Pubmed
Tempone,
Antiprotozoal activity of Brazilian plant extracts from isoquinoline alkaloid-producing families.
2005,
Pubmed
Tempone,
Natural products to anti-trypanosomal drugs: an overview of new drug prototypes for American Trypanosomiasis.
2007,
Pubmed
Trouiller,
Drugs for neglected diseases: a failure of the market and a public health failure?
2001,
Pubmed
Yadava,
A new biologically active flavone glycoside from the seeds of Cassia fistula (Linn.).
2003,
Pubmed
