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ECB-ART-40726
Front Biosci 2008 May 01;13:4740-55. doi: 10.2741/3036.
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Trimeric G protein-dependent signaling by Frizzled receptors in animal development.

Egger-Adam D , Katanaev VL .


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Receptors of the Frizzled family transduce important signals during animal development and are conserved from sponges to humans. Frizzled receptors belong to the superfamily of G protein-coupled receptors (GPCRs), but until recently were considered G protein-independent in their signaling. In the present article we review the extensive knowledge demonstrating the functions of trimeric G proteins in Frizzled signal transduction in vertebrates and lower animals. Other structural and functional similarities of Frizzled receptors and the GPCRs are also discussed.

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