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NAADP (nicotinic acid-adenine dinucleotide phosphate), the most potent Ca2+-mobilizing second messenger, is active in a wide range of organisms and cell types. Until now, all NAADP-producing enzymes have been thought to be members of the ADP-ribosyl cyclase family. ADP-ribosyl cyclases exhibit promiscuous substrate selectivity, synthesize a variety of products and are regulated in a limited manner, which may be non-physiological. In the present paper, we report the presence of an enzyme on the surface of sea urchin sperm that exhibits bell-shaped regulation by Ca2+ over a range (EC(50) of 10 nM and IC(50) of 50 microM) that is physiologically relevant. Uniquely, this surface enzyme possesses complete selectivity for nucleotides with a 2''-phosphate group and exhibits only base-exchange activity without any detectable cyclase activity. Taken together, these findings indicate that this novel enzyme should be considered as the first true NAADP synthase.
Aarhus,
Activation and inactivation of Ca2+ release by NAADP+.
1996, Pubmed,
Echinobase
Aarhus,
Activation and inactivation of Ca2+ release by NAADP+.
1996,
Pubmed
,
Echinobase
Aarhus,
ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP.
1995,
Pubmed
Allen,
Regulation of inositol lipid-specific phospholipase cdelta by changes in Ca2+ ion concentrations.
1997,
Pubmed
Bacher,
Channelling of substrate promiscuity of the skeletal-muscle ADP-ribosyl cyclase isoform.
2004,
Pubmed
Berridge,
Calcium microdomains: organization and function.
2006,
Pubmed
Berridge,
Metabolism of the novel Ca2+-mobilizing messenger nicotinic acid-adenine dinucleotide phosphate via a 2'-specific Ca2+-dependent phosphatase.
2002,
Pubmed
Billington,
Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoa.
2006,
Pubmed
Boittin,
Nicotinic acid adenine dinucleotide phosphate mediates Ca2+ signals and contraction in arterial smooth muscle via a two-pool mechanism.
2002,
Pubmed
Cakir-Kiefer,
Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD(+) glycohydrolases.
2000,
Pubmed
Ceni,
The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.
2006,
Pubmed
Chini,
Nicotinate-adenine dinucleotide phosphate-induced Ca(2+)-release does not behave as a Ca(2+)-induced Ca(2+)-release system.
1996,
Pubmed
,
Echinobase
Chini,
Cyclic ADP-ribose signaling in sea urchin gametes: metabolism in spermatozoa.
1997,
Pubmed
,
Echinobase
Chini,
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
2002,
Pubmed
Churamani,
Molecular characterization of a novel intracellular ADP-ribosyl cyclase.
2007,
Pubmed
,
Echinobase
Churchill,
Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients.
2000,
Pubmed
,
Echinobase
Churchill,
NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.
2001,
Pubmed
,
Echinobase
Churchill,
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs.
2002,
Pubmed
,
Echinobase
Churchill,
Sperm deliver a new second messenger: NAADP.
2003,
Pubmed
,
Echinobase
De Flora,
The CD38/cyclic ADP-ribose system: a topological paradox.
1997,
Pubmed
,
Echinobase
de Toledo,
ADP-Ribosyl cyclase in rat vascular smooth muscle cells: properties and regulation.
2000,
Pubmed
Galione,
The NAADP receptor: new receptors or new regulation?
2005,
Pubmed
,
Echinobase
Genazzani,
Unique inactivation properties of NAADP-sensitive Ca2+ release.
1996,
Pubmed
,
Echinobase
Gerasimenko,
NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area.
2006,
Pubmed
Gerasimenko,
NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors.
2003,
Pubmed
Goodrich,
Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoni.
2005,
Pubmed
Graeff,
Enzymatic synthesis and characterizations of cyclic GDP-ribose. A procedure for distinguishing enzymes with ADP-ribosyl cyclase activity.
1994,
Pubmed
,
Echinobase
Graeff,
Cyclic GMP-dependent and -independent effects on the synthesis of the calcium messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.
1998,
Pubmed
,
Echinobase
Graeff,
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities.
2006,
Pubmed
Gray,
Guanylate cyclase of sea urchin sperm: subcellular localization.
1976,
Pubmed
,
Echinobase
Hirata,
ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1.
1994,
Pubmed
Hohenegger,
Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor.
2002,
Pubmed
Howard,
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.
1993,
Pubmed
Kukimoto,
Stimulation of ADP-ribosyl cyclase activity of the cell surface antigen CD38 by zinc ions resulting from inhibition of its NAD+ glycohydrolase activity.
1996,
Pubmed
Lee,
ADP-ribosyl cyclase and CD38. Multi-functional enzymes in Ca+2 signaling.
1997,
Pubmed
Lee,
Enzymatic functions and structures of CD38 and homologs.
2000,
Pubmed
Lee,
Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity.
1989,
Pubmed
,
Echinobase
Lee,
Structure and enzymatic functions of human CD38.
2006,
Pubmed
Lee,
A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose.
1995,
Pubmed
,
Echinobase
Lee,
A unified mechanism of enzymatic synthesis of two calcium messengers: cyclic ADP-ribose and NAADP.
1999,
Pubmed
Macgregor,
NAADP controls cross-talk between distinct Ca2+ stores in the heart.
2007,
Pubmed
Munshi,
The homo-dimeric form of ADP-ribosyl cyclase in solution.
1998,
Pubmed
Palade,
The hunt for an alternate way to generate NAADP. Focus on "NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells".
2007,
Pubmed
Patton,
Some precautions in using chelators to buffer metals in biological solutions.
2004,
Pubmed
Sauve,
The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries.
1998,
Pubmed
Soares,
NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells.
2007,
Pubmed
Streb,
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.
1983,
Pubmed
Sutovsky,
Paternal contributions to the mammalian zygote: fertilization after sperm-egg fusion.
2000,
Pubmed
Torti,
Hydrolysis of NADP+ by platelet CD38 in the absence of synthesis and degradation of cyclic ADP-ribose 2'-phosphate.
1999,
Pubmed
Tsien,
Measurement of cytosolic free Ca2+ with quin2.
1989,
Pubmed
White,
Nitric oxide inhibits ADP-ribosyl cyclase through a cGMP-independent pathway in airway smooth muscle.
2002,
Pubmed
Wilson,
Differential regulation of nicotinic acid-adenine dinucleotide phosphate and cADP-ribose production by cAMP and cGMP.
1998,
Pubmed
,
Echinobase
Young,
Sphingosine 1-phosphate: a Ca2+ release mediator in the balance.
2002,
Pubmed
Zielinska,
Metabolism of cyclic ADP-ribose: Zinc is an endogenous modulator of the cyclase/NAD glycohydrolase ratio of a CD38-like enzyme from human seminal fluid.
2004,
Pubmed
,
Echinobase
Zocchi,
A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes.
1993,
Pubmed
