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PLoS One
2007 Sep 12;29:e879. doi: 10.1371/journal.pone.0000879.
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Dating phylogenies with hybrid local molecular clocks.
Aris-Brosou S
.
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BACKGROUND: Because rates of evolution and species divergence times cannot be estimated directly from molecular data, all current dating methods require that specific assumptions be made before inferring any divergence time. These assumptions typically bear either on rates of molecular evolution (molecular clock hypothesis, local clocks models) or on both rates and times (penalized likelihood, Bayesian methods). However, most of these assumptions can affect estimated dates, oftentimes because they underestimate large amounts of rate change.
PRINCIPAL FINDINGS: A significant modification to a recently proposed ad hoc rate-smoothing algorithm is described, in which local molecular clocks are automatically placed on a phylogeny. This modification makes use of hybrid approaches that borrow from recent theoretical developments in microarray data analysis. An ad hoc integration of phylogenetic uncertainty under these local clock models is also described. The performance and accuracy of the new methods are evaluated by reanalyzing three published data sets.
CONCLUSIONS: It is shown that the new maximum likelihood hybrid methods can perform better than penalized likelihood and almost as well as uncorrelated Bayesian models. However, the new methods still tend to underestimate the actual amount of rate change. This work demonstrates the difficulty of estimating divergence times using local molecular clocks.
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17849008
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Figure 1. Effect of the number of local clocks on the age of a node far from all calibration points.Times were estimated using either the original AHRS algorithm or k-means and are given in million years ago (MYA). The focal node is the split at the origin of the mouse lemurs (genus Microcebus).
Figure 2. Maximum likelihood score as a function of the number of clocks.
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