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Regulatory networks of transcription factors and signaling molecules lie at the heart of development. Their architecture implements logic functions whose execution propels cells from one regulatory state to the next, thus driving development forward. As an example of a subcircuit that translates transcriptional input into developmental output, we consider a particularly simple case, the regulatory processes underlying pigment cell formation in sea urchin embryos. The regulatory events in this process can be represented as elementary logic functions.
Ben-Tabou de-Leon,
Gene regulation: gene control network in development.
2007, Pubmed,
Echinobase
Ben-Tabou de-Leon,
Gene regulation: gene control network in development.
2007,
Pubmed
,
Echinobase
Calestani,
Isolation of pigment cell specific genes in the sea urchin embryo by differential macroarray screening.
2003,
Pubmed
,
Echinobase
Davidson,
A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo.
2002,
Pubmed
,
Echinobase
Davidson,
Specification of cell fate in the sea urchin embryo: summary and some proposed mechanisms.
1998,
Pubmed
,
Echinobase
Geier,
Reconstructing gene-regulatory networks from time series, knock-out data, and prior knowledge.
2007,
Pubmed
Howard-Ashby,
High regulatory gene use in sea urchin embryogenesis: Implications for bilaterian development and evolution.
2006,
Pubmed
,
Echinobase
Istrail,
Logic functions of the genomic cis-regulatory code.
2005,
Pubmed
,
Echinobase
Lai,
Notch signaling: control of cell communication and cell fate.
2004,
Pubmed
Longabaugh,
Computational representation of developmental genetic regulatory networks.
2005,
Pubmed
Oliveri,
Development. Built to run, not fail.
2007,
Pubmed
Oliveri,
Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo.
2006,
Pubmed
,
Echinobase
Range,
LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo.
2005,
Pubmed
,
Echinobase
Ransick,
cis-regulatory processing of Notch signaling input to the sea urchin glial cells missing gene during mesoderm specification.
2006,
Pubmed
,
Echinobase
Ruffins,
A fate map of the vegetal plate of the sea urchin (Lytechinus variegatus) mesenchyme blastula.
1996,
Pubmed
,
Echinobase
Satou,
Cataloging transcription factor and major signaling molecule genes for functional genomic studies in Ciona intestinalis.
2005,
Pubmed
Sherwood,
LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.
1999,
Pubmed
,
Echinobase
Stathopoulos,
Genomic regulatory networks and animal development.
2005,
Pubmed
Walton,
Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development.
2006,
Pubmed
,
Echinobase
