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ECB-ART-40158
J Fluoresc 2007 May 01;173:289-92. doi: 10.1007/s10895-007-0171-7.
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Study of blood porphyrin spectral profile for diagnosis of tumor progression.

Courrol LC , de Oliveira Silva FR , Coutinho EL , Piccoli MF , Mansano RD , Vieira Júnior ND , Schor N , Bellini MH .


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Renal cell carcinoma (RCC) accounts for approximately 3% of new cancer incidence and mortality in the United States. Unfortunately many RCC masses remain asymptomatic and nonpalpable until they are advanced. Diagnosis and localization of early carcinoma play an important role in the prevention and curative treatment of RCC. The autofluorescence of blood porphyrin of healthy and tumor induced in male SCID mice was analyzed using fluorescence and excitation spectroscopy. A significant contrast between normal and tumor blood could be established. Blood porphyrin fluorophore showed enhanced fluorescence band (around 630 nm) in function of the tumor growth. This indicates that either the autofluorescence intensity of the blood fluorescence may provide a good parameter for the "first approximation" characterization of the tumor stage.

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Genes referenced: LOC115919910

References [+] :
Ferreira, Reaction-diffusion model for the growth of avascular tumor. 2002, Pubmed