ECB-ART-40131
Biosci Biotechnol Biochem
2007 Mar 01;713:830-3. doi: 10.1271/bbb.60651.
Show Gene links
Show Anatomy links
Enzymatic synthesis of dehydroderivatives from proline-containing cyclic dipeptides and their effects toward cell division.
???displayArticle.abstract???
We have previously isolated cyclo(L-Pro-L-Tyr) and cyclo(L-Phe-L-Pro) from an actinomycete by a novel enzymatic conversion-guided method. Their tetradehydro derivatives, cyclo(DeltaPro-DeltaTyr) and cyclo(DeltaPhe-DeltaPro), were enzymatically prepared. Neither of them inhibited cell division, in contrast to other tetradehydro cyclic dipeptides prepared previously. This result suggests that an NH proton in a diketopiperazine ring and/or conformation of the compound are important for the activity.
???displayArticle.pubmedLink??? 17341821
???displayArticle.link??? Biosci Biotechnol Biochem
Genes referenced: LOC115919910 pelp1 pus1