ECB-ART-39831
Bioorg Med Chem
2006 Sep 15;1418:6434-43. doi: 10.1016/j.bmc.2006.05.036.
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Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.
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In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated.
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Genes referenced: cdk1 gsk3a LOC115918615 LOC115919910