Neurosci Lett 2006 Aug 14;4041-2:15-9. doi: 10.1016/j.neulet.2006.05.009.

Neural calcitropic peptides: immunoreactive characterization in fish and invertebrates.

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Parathyroid hormone (PTH) and stanniocalcin (STC) are primarily produced by the parathyroid glands and corpuscles of Stannius in tetrapods and fish, respectively. However, it is now known that both calcitropic peptides are also synthesized outside of these specialized endocrine glands. The current study employed Western blot analysis to characterize PTH and STC in neural tissues of high- (rats) and low- (hagfish, dogfish, rockfish, trout and skate) vertebrates and invertebrates (starfish, squid, cuttlefish, snails, prawns). Immunoreactive PTH-like peptides, comparable in size to PTH 1-84, were readily detectable in brains of vertebrates lacking (fish) and possessing (rat) parathyroid glands and in invertebrate (snail) ganglia. Immunoreactive STC-like peptides of varying size were similarly detected in brains of vertebrates lacking (rat) and possessing (fish) corpuscles of Stannius and in invertebrate (snail, prawn) ganglia. STC and PTH may thus have evolved as ancestral neuropeptides.

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Genes referenced: snai2