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Philos Trans R Soc Lond B Biol Sci
2005 Dec 29;3601464:2301-8. doi: 10.1098/rstb.2005.1767.
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Dual oxidases.
Donkó A
,
Péterfi Z
,
Sum A
,
Leto T
,
Geiszt M
.
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Reactive oxygen species (ROS) have an important role in various physiological processes including host defence, mitogenesis, hormone biosynthesis, apoptosis and fertilization. Currently, the most characterized ROS-producing system operates in phagocytic cells, where ROS generated during phagocytosis act in host defence. Recently, several novel homologues of the phagocytic oxidase have been discovered and this protein family is now designated as the NOX/DUOX family of NADPH oxidases. NOX/DUOX enzymes function in a variety of tissues, including colon, kidney, thyroid gland, testis, salivary glands, airways and lymphoid organs. Importantly, members of the enzyme family are also found in non-mammalian species, including Caenorhabditis elegans and sea urchin. The physiological functions of novel NADPH oxidase enzymes are currently largely unknown. This review focuses on our current knowledge about dual oxidases.
Ambasta,
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase.
2004, Pubmed
Ambasta,
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase.
2004,
Pubmed
Bokoch,
NADPH oxidases: not just for leukocytes anymore!
2003,
Pubmed
De Deken,
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
2000,
Pubmed
De Deken,
Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.
2002,
Pubmed
Dupuy,
Ca2+ regulation of thyroid NADPH-dependent H2O2 generation.
1988,
Pubmed
Dupuy,
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.
1999,
Pubmed
Edens,
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.
2001,
Pubmed
El Hassani,
Dual oxidase2 is expressed all along the digestive tract.
2005,
Pubmed
Fortemaison,
Regulation of H2O2 generation in thyroid cells does not involve Rac1 activation.
2005,
Pubmed
Forteza,
Regulated hydrogen peroxide production by Duox in human airway epithelial cells.
2005,
Pubmed
Geiszt,
Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.
2003,
Pubmed
Geiszt,
The Nox family of NAD(P)H oxidases: host defense and beyond.
2004,
Pubmed
Gerson,
The lactoperoxidase system functions in bacterial clearance of airways.
2000,
Pubmed
Heinecke,
The respiratory burst oxidase of fertilization. A physiological target for regulation by protein kinase C.
1992,
Pubmed
Kamath,
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.
2003,
Pubmed
Lambeth,
NOX enzymes and the biology of reactive oxygen.
2004,
Pubmed
Morand,
Targeting of the dual oxidase 2 N-terminal region to the plasma membrane.
2004,
Pubmed
Moreno,
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.
2002,
Pubmed
Pachucki,
Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions.
2004,
Pubmed
Quinn,
Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases.
2004,
Pubmed
Reite,
Bacterial inhibitors in milk and other biological fluids.
1967,
Pubmed
Riedel,
Journey of the iodide transporter NIS: from its molecular identification to its clinical role in cancer.
2001,
Pubmed
Schwarzer,
NADPH oxidase-dependent acid production in airway epithelial cells.
2004,
Pubmed
Takeya,
Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.
2003,
Pubmed
Wang,
Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.
2005,
Pubmed
Wong,
The oxidative burst at fertilization is dependent upon activation of the dual oxidase Udx1.
2004,
Pubmed
,
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