ECB-ART-39543
J Nat Prod
2005 Aug 01;688:1213-7. doi: 10.1021/np050115m.
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SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis.
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An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.
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Genes referenced: mrpl44 serca