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Origin and evolution of Kinesin-like calmodulin-binding protein.
Abdel-Ghany SE
,
Day IS
,
Simmons MP
,
Kugrens P
,
Reddy AS
.
???displayArticle.abstract??? Kinesin-like calmodulin-binding protein (KCBP), a member of the Kinesin-14 family, is a C-terminal microtubule motor with three unique domains including a myosin tail homology region 4 (MyTH4), a talin-like domain, and a calmodulin-binding domain (CBD). The MyTH4 and talin-like domains (found in some myosins) are not found in other reported kinesins. A calmodulin-binding kinesin called kinesin-C (SpKinC) isolated from sea urchin (Strongylocentrotus purpuratus) is the only reported kinesin with a CBD. Analysis of the completed genomes of Homo sapiens, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and a red alga (Cyanidioschyzon merolae 10D) did not reveal the presence of a KCBP. This prompted us to look at the origin of KCBP and its relationship to SpKinC. To address this, we isolated KCBP from a gymnosperm, Picea abies, and a green alga, Stichococcus bacillaris. In addition, database searches resulted in identification of KCBP in another green alga, Chlamydomonas reinhardtii, and several flowering plants. Gene tree analysis revealed that the motor domain of KCBPs belongs to a clade within the Kinesin-14 (C-terminal motors) family. Only land plants and green algae have a kinesin with the MyTH4 and talin-like domains of KCBP. Further, our analysis indicates that KCBP is highly conserved in green algae and land plants. SpKinC from sea urchin, which has the motor domain similar to KCBP and contains a CBD, lacks the MyTH4 and talin-like regions. Our analysis indicates that the KCBPs, SpKinC, and a subset of the kinesin-like proteins are all more closely related to one another than they are to any other kinesins, but that either KCBP gained the MyTH4 and talin-like domains or SpKinC lost them.
Abdel-Ghany,
A novel calcium/calmodulin-regulated kinesin-like protein is highly conserved between monocots and dicots.
2000, Pubmed
Abdel-Ghany,
A novel calcium/calmodulin-regulated kinesin-like protein is highly conserved between monocots and dicots.
2000,
Pubmed
Abdel-Ghany,
CpKLP1: A CALMODULIN-BINDING KINESIN-LIKE PROTEIN FROM CYANOPHORA PARADOXA (GLAUCOPHYTA).
2000,
Pubmed
,
Echinobase
Ambrose,
A minus-end-directed kinesin with plus-end tracking protein activity is involved in spindle morphogenesis.
2005,
Pubmed
Asada,
Isolation of polypeptides with microtubule-translocating activity from phragmoplasts of tobacco BY-2 cells.
1994,
Pubmed
Asada,
TKRP125, a kinesin-related protein involved in the centrosome-independent organization of the cytokinetic apparatus in tobacco BY-2 cells.
1997,
Pubmed
Baldauf,
The deep roots of eukaryotes.
2003,
Pubmed
Barroso,
Two kinesin-related proteins associated with the cold-stable cytoskeleton of carrot cells: characterization of a novel kinesin, DcKRP120-2.
2000,
Pubmed
Barton,
Going mobile: microtubule motors and chromosome segregation.
1996,
Pubmed
Bowser,
Localization of a kinesin-like calmodulin-binding protein in dividing cells of Arabidopsis and tobacco.
1997,
Pubmed
Case,
Role of the kinesin neck linker and catalytic core in microtubule-based motility.
2000,
Pubmed
Chen,
The Arabidopsis ATK1 gene is required for spindle morphogenesis in male meiosis.
2002,
Pubmed
Cummings,
Comparing bootstrap and posterior probability values in the four-taxon case.
2003,
Pubmed
Day,
Interaction of a kinesin-like calmodulin-binding protein with a protein kinase.
2000,
Pubmed
Deavours,
Ca2+/calmodulin regulation of the Arabidopsis kinesin-like calmodulin-binding protein.
1998,
Pubmed
Doolittle,
Evolutionarily mobile modules in proteins.
1993,
Pubmed
Endow,
Determinants of kinesin motor polarity.
1998,
Pubmed
Farris,
PARSIMONY JACKKNIFING OUTPERFORMS NEIGHBOR-JOINING.
1996,
Pubmed
Felsenstein,
CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP.
1985,
Pubmed
Folkers,
The cell morphogenesis gene ANGUSTIFOLIA encodes a CtBP/BARS-like protein and is involved in the control of the microtubule cytoskeleton.
2002,
Pubmed
Goldstein,
The road less traveled: emerging principles of kinesin motor utilization.
1999,
Pubmed
Golovkin,
Structure and expression of a plant U1 snRNP 70K gene: alternative splicing of U1 snRNP 70K pre-mRNAs produces two different transcripts.
1996,
Pubmed
Goodson,
Molecular phylogeny of the kinesin family of microtubule motor proteins.
1994,
Pubmed
Hirokawa,
Kinesin and dynein superfamily proteins and the mechanism of organelle transport.
1998,
Pubmed
Huelsenbeck,
MRBAYES: Bayesian inference of phylogenetic trees.
2001,
Pubmed
Itoh,
Kinesin-related proteins with a mitochondrial targeting signal.
2001,
Pubmed
Iwabe,
Kinesin-related genes from diplomonad, sponge, amphioxus, and cyclostomes: divergence pattern of kinesin family and evolution of giardial membrane-bounded organella.
2002,
Pubmed
Kao,
Bundling of microtubules by motor and tail domains of a kinesin-like calmodulin-binding protein from Arabidopsis: regulation by Ca(2+)/Calmodulin.
2000,
Pubmed
Kim,
A kinesin family tree.
2000,
Pubmed
Kong,
A geminivirus replication protein interacts with a protein kinase and a motor protein that display different expression patterns during plant development and infection.
2002,
Pubmed
Kull,
The case for a common ancestor: kinesin and myosin motor proteins and G proteins.
1998,
Pubmed
Lassmann,
Quality assessment of multiple alignment programs.
2002,
Pubmed
Lawrence,
Maximum likelihood methods reveal conservation of function among closely related kinesin families.
2002,
Pubmed
Lawrence,
A standardized kinesin nomenclature.
2004,
Pubmed
Lee,
Identification of a phragmoplast-associated kinesin-related protein in higher plants.
2000,
Pubmed
Lee,
Cytoskeletal motors in Arabidopsis. Sixty-one kinesins and seventeen myosins.
2004,
Pubmed
Lee,
A novel plant kinesin-related protein specifically associates with the phragmoplast organelles.
2001,
Pubmed
Leopold,
Association of kinesin with characterized membrane-bounded organelles.
1992,
Pubmed
Lewis,
Green algae and the origin of land plants.
2004,
Pubmed
Liu,
A kinesin-like protein, KatAp, in the cells of arabidopsis and other plants.
1996,
Pubmed
Lu,
An internal motor kinesin is associated with the Golgi apparatus and plays a role in trichome morphogenesis in Arabidopsis.
2005,
Pubmed
Manning,
Drivers and passengers wanted! the role of kinesin-associated proteins.
2000,
Pubmed
Marcus,
Arabidopsis thaliana protein, ATK1, is a minus-end directed kinesin that exhibits non-processive movement.
2002,
Pubmed
Matsuzaki,
Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D.
2004,
Pubmed
Matthies,
Calmodulin binding to and cAMP-dependent phosphorylation of kinesin light chains modulate kinesin ATPase activity.
1993,
Pubmed
Miki,
All kinesin superfamily protein, KIF, genes in mouse and human.
2001,
Pubmed
Mitsui,
Sequencing and characterization of the kinesin-related genes katB and katC of Arabidopsis thaliana.
1994,
Pubmed
Mitsui,
Identification of a gene family (kat) encoding kinesin-like proteins in Arabidopsis thaliana and the characterization of secondary structure of KatA.
1993,
Pubmed
Moore,
Kinesin proteins: a phylum of motors for microtubule-based motility.
1996,
Pubmed
Morgenstern,
DIALIGN 2: improvement of the segment-to-segment approach to multiple sequence alignment.
1999,
Pubmed
Morgenstern,
DIALIGN: finding local similarities by multiple sequence alignment.
1998,
Pubmed
Narasimhulu,
Interaction of Arabidopsis kinesin-like calmodulin-binding protein with tubulin subunits: modulation by Ca(2+)-calmodulin.
1997,
Pubmed
Narasimhulu,
Characterization of microtubule binding domains in the Arabidopsis kinesin-like calmodulin binding protein.
1998,
Pubmed
Nishihama,
Expansion of the cell plate in plant cytokinesis requires a kinesin-like protein/MAPKKK complex.
2002,
Pubmed
Nixon,
ON OUTGROUPS.
1993,
Pubmed
Oppenheimer,
Essential role of a kinesin-like protein in Arabidopsis trichome morphogenesis.
1997,
Pubmed
Pan,
Localization of two homologous Arabidopsis kinesin-related proteins in the phragmoplast.
2004,
Pubmed
Philippe,
Phylogenomics of eukaryotes: impact of missing data on large alignments.
2004,
Pubmed
Preuss,
The cotton kinesin-like calmodulin-binding protein associates with cortical microtubules in cotton fibers.
2003,
Pubmed
Preuss,
A plant-specific kinesin binds to actin microfilaments and interacts with cortical microtubules in cotton fibers.
2004,
Pubmed
Raich,
Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4.
1998,
Pubmed
Rannala,
Probability distribution of molecular evolutionary trees: a new method of phylogenetic inference.
1996,
Pubmed
Reddy,
A plant calmodulin-binding motor is part kinesin and part myosin.
1999,
Pubmed
Reddy,
Molecular motors and their functions in plants.
2001,
Pubmed
Reddy,
Kinesins in the Arabidopsis genome: a comparative analysis among eukaryotes.
2001,
Pubmed
Reddy,
The calmodulin-binding domain from a plant kinesin functions as a modular domain in conferring Ca2+-calmodulin regulation to animal plus- and minus-end kinesins.
2002,
Pubmed
Reddy,
KIC, a novel Ca2+ binding protein with one EF-hand motif, interacts with a microtubule motor protein and regulates trichome morphogenesis.
2004,
Pubmed
Reddy,
A novel plant calmodulin-binding protein with a kinesin heavy chain motor domain.
1996,
Pubmed
Reddy,
A plant kinesin heavy chain-like protein is a calmodulin-binding protein.
1996,
Pubmed
Reddy,
The role of the cytoskeleton and a molecular motor in trichome morphogenesis.
2000,
Pubmed
Rogers,
Identification of kinesin-C, a calmodulin-binding carboxy-terminal kinesin in animal (Strongylocentrotus purpuratus) cells.
1999,
Pubmed
,
Echinobase
Sanderson,
Parametric phylogenetics?
2000,
Pubmed
Sawin,
Mitotic spindle organization by a plus-end-directed microtubule motor.
1992,
Pubmed
Schoch,
A complete inventory of fungal kinesins in representative filamentous ascomycetes.
2003,
Pubmed
Siddiqui,
Metazoan motor models: kinesin superfamily in C. elegans.
2002,
Pubmed
Simmons,
Amino acid vs. nucleotide characters: challenging preconceived notions.
2002,
Pubmed
Simmons,
How meaningful are Bayesian support values?
2004,
Pubmed
Simmons,
Efficiently resolving the basal clades of a phylogenetic tree using Bayesian and parsimony approaches: a case study using mitogenomic data from 100 higher teleost fishes.
2004,
Pubmed
Simmons,
Gaps as characters in sequence-based phylogenetic analyses.
2000,
Pubmed
Simmons,
A Fundamental Problem with Amino-Acid-Sequence Characters for Phylogenetic Analyses.
2000,
Pubmed
Simmons,
Artifacts of Coding Amino Acids and Other Composite Characters for Phylogenetic Analysis.
2002,
Pubmed
Simmons,
Conflict between Amino Acid and Nucleotide Characters.
2002,
Pubmed
Smirnova,
Minus end-directed kinesin-like motor protein, Kcbp, localizes to anaphase spindle poles in Haemanthus endosperm.
1998,
Pubmed
Smith,
Evolution by acquisition: the case for horizontal gene transfers.
1992,
Pubmed
Song,
In vitro motility of AtKCBP, a calmodulin-binding kinesin protein of Arabidopsis.
1997,
Pubmed
Stewart,
The case for a polyphyletic origin of mitochondria: morphological and molecular comparisons.
1984,
Pubmed
Strompen,
The Arabidopsis HINKEL gene encodes a kinesin-related protein involved in cytokinesis and is expressed in a cell cycle-dependent manner.
2002,
Pubmed
Suzuki,
Overcredibility of molecular phylogenies obtained by Bayesian phylogenetics.
2002,
Pubmed
Tamura,
Characterization of katD, a kinesin-like protein gene specifically expressed in floral tissues of Arabidopsis thaliana.
1999,
Pubmed
Tanaka,
The AtNACK1/HINKEL and STUD/TETRASPORE/AtNACK2 genes, which encode functionally redundant kinesins, are essential for cytokinesis in Arabidopsis.
2004,
Pubmed
Thompson,
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
1997,
Pubmed
Tiezzi,
An immunoreactive homolog of mammalian kinesin in Nicotiana tabacum pollen tubes.
1992,
Pubmed
Vale,
The molecular motor toolbox for intracellular transport.
2003,
Pubmed
Vale,
The design plan of kinesin motors.
1997,
Pubmed
Vinogradova,
Crystal structure of kinesin regulated by Ca(2+)-calmodulin.
2004,
Pubmed
Vos,
The kinesin-like calmodulin binding protein is differentially involved in cell division.
2000,
Pubmed
Wang,
Divergence time estimates for the early history of animal phyla and the origin of plants, animals and fungi.
1999,
Pubmed
Wang,
A novel kinesin-like protein with a calmodulin-binding domain.
1996,
Pubmed
Weber,
A microtubule-binding myosin required for nuclear anchoring and spindle assembly.
2004,
Pubmed
Wein,
DSK1, a novel kinesin-related protein from the diatom Cylindrotheca fusiformis that is involved in anaphase spindle elongation.
1996,
Pubmed
Yang,
TETRASPORE encodes a kinesin required for male meiotic cytokinesis in Arabidopsis.
2003,
Pubmed
Yang,
Bayesian phylogenetic inference using DNA sequences: a Markov Chain Monte Carlo Method.
1997,
Pubmed
Zhong,
A kinesin-like protein is essential for oriented deposition of cellulose microfibrils and cell wall strength.
2002,
Pubmed
